Registration Dossier
Registration Dossier
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EC number: 203-354-6 | CAS number: 106-02-5
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Weight of evidence approach (EC number: 422-320-3):
No effects were observed on fish over 96 hours study period at any concentration up to the solubility limit of the substance.
No acute LC50 value can be calculated for fish.
Key value for chemical safety assessment
Additional information
Three weight of evidence studies are available to assess the short-term toxicity of the substance to fish.
The first weight of evidence study (Caspers, 1994) was performed according to EU Method C.1 with GLP statement on the registered substance but was not deemed as reliable as aeration was used and substance loss may have occurred due to this.
The two other weight of evidence studies (Stäbler, 2005; Sewell, 1995) were performed according to OECD Guideline 203 and EU Method C.1 with GLP statement on the read-across substance (EC Number: 422-320-3) and were considered reliable with restrictions. No effects were observed on fish over a 96 hours study period at any concentration up to the solubility limit of the test substance. Therefore, no acute LC50 value can be calculated for fish.
The supporting substance is considered adequate for read-across purposes (see Iuclid section 13 for justification).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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