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The toxicology of ITC 288/S has been investigated in oral study (OECD 407, Kr:1), leading to the conclusion that this substance is of very low  toxicity, NOAEL ≥ 1000 mg/kg bw/day, any systemic toxicity was reported (test proposal for 90 days/oral was made). The genotoxic potential of ITC 288/S has been investigated both in vitro and in vivo. ITC 288/S is considered as not genotoxic.
Although no chronic carcinogenicity study has been performed, the available data indicate that ITC 288/S does not present a carcinogenic hazard.

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