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EC number: 221-242-5 | CAS number: 3039-83-6
In a guinea pig maximisation test according to OECD 406 and GLP guideline (Hoechst AG (a), 1988) a test solution containing 30 % Sodium etyhlenesulphonate was used. For the determination of the non-irritating concentration and of the intradermal tolerance a range finding test was conducted. Thereby, 0.5 mL undiluted test solution (30 % Sodium ethylenesulphonate) induced erythema, slight edema and pustules whereas 10 % test solution (3 % Sodium ethylenesulphonate) induced no skin irritations after epicutaneous occlusive exposure (24 hours) on the right and left flank of 6 animals. In the main study ten female Pribright-Hartley guinea pigs were treated on day 1 by two intradermal injections on the back in three areas with 50 % Freund´s Adjuvant (1. area, 2 x 0.1 mL), 5 % test solution in 0.9 % NaCl (2. area 2 x 0.1 mL, 1.5 % Sodium etyhlenesulphonate) and 5 % test solution in Freund´s Adjuvant (3. area, 2 x 0.1 mL, 1.5 % Sodium etyhlenesulphonate). On day 9, ten animals received 0.5 mL of the test solution by dermal application on the intradermal injection area (back), occlusive, for an exposure time of 48 hours. Thereby, animals were treated with 10 % test solution in 0.9% NaCl (3 % Sodium ethylensulphonate). Five control animals and five animals of a satellite group were treated with a 0.9 % NaCl solution. On challenge exposure (day 22) animals (ten for the treated group and five for the control group) were treated with 0.5 mL of the test solution on the left flank by an occlusive dressing for an exposure time of 24 hours. All animals received 10 % test solution in 0.9 % NaCl (3 % Sodium ethylenesulphonate). 24h and 48h after the occlusive gauze was removed the animals of the treated and the control goup revealed no signs of skin irritation
Based on the results obtained in the key skin sensitisation test, Sodium ethylenesulphonate is not subject to classification for sensitization according to Directive 67/548/EEC and according to Regulation (EC) No 1272/2008.
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