Registration Dossier
Registration Dossier
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EC number: 203-963-7 | CAS number: 112-36-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Justification for classification or non-classification
The acute oral LD50 for Diethylene Glycol Diethyl Ether is 4970mg/kg bw in male rats and 3674.3mg/kg bw in female mice.
The acute dermal LD50 values for Diethylene Glycol Ethyl Ether and Diethylene Glycol Methyl Ethyl Ether are 6000 and 6420mg/kg bw in rats, respectively. These two substances are used as read across for the classification of acute dermal toxicity of DEGDEE (see Category Approach-Read across Bis(2 -ethoxyethyl)ether, 2013).
The acute inhalation LC50 of diethylene glycol dimethyl ether in rats after 7 h inhalation exposure is >11 mg/L (saturated atmosphere).The acute dermal LD50 value for Diethylene Glycol Ethyl Ether is >5.24 mg/L (mists) in rats. These two substances are used as read across for the classification of acute toxicity of DEGDEE by the inhalation route (see Category Approach-Read across Bis(2 -ethoxyethyl)ether, 2013).
Based on these results, DEGDEE is not classified as acutely toxic according to CLP criteria (Regulation (EC) No 1272/2008).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
