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EC number: 217-886-1 | CAS number: 1999-85-5
According to “The guidelines for the testing of chemicals” (HJ/T 153 -2004) and with reference to Procedure 106 of the“Guidelines for Testing of Chemicals” of the OECD: “Bioconcentration: Semi-static Fish Test ”(OECD TG 305B), the bioconcentration factor (BCFs) of the substance (meta-Diisopropanolbenzene) in fish (Brachydanio rerio) was tested.
The bioconcentration test was performed using zebrafish. The test fish were exposed to the concentrations of the test substance with 1 and 10 mg/L under semi-static conditions with 48h renewal. BCF values were measured following 28-day exposure period.
The water sample of the test substance was analyzed emplying UPLC-PDA. The retention time of it was approximate 2.65 min.The linear regression equation of meta-Diisopropanolbenzene was: y = 47326.5 x - 174.1, with good linearity of r2=0.99996 for 0.20~10.0 mg/L.
The fish sample of the test substance was analyzed emplying UPLC-PDA. The retention time of it was approximate 2.950 min.The linear regression equation of meta-Diisopropanolbenzene was: y = 9505.2 x - 1190.9, with good linearity of r2=0.99996 for 1.0~50.0 mg/kg.
The recovery in the water sample was between 92.1%~93.1% and RSD was 3.18%~ 3.78%, when the added concentration of the test substance is 1.00~10.0 mg/L in water samples. The recovery in the fish sample was between 94.6%~99.8% and RSD was 0.67%~4.99%, while the added concentration of the test substance is 1~10 mg/kg in fish samples. The minimum detection amount of PDA detector for meta-Diisopropanolbenzene is1.0×10 -9 g, and the minimum detection concentration for water and fish sample is 0.20 mg/L and 1.0 mg/kg.
The results show that the BCF value of meta-Diisopropanolbenzene is < 1~3.99 (at 1 mg/L) and < 1~2.08 (at 10 mg/L).The bioconcentrationfactor of meta-Diisopropanolbenzene in fish was below 100, so the test substance has low bioconcentration effect on fish during the exposure period of 28 days.
The results show that the BCF value of meta-Diisopropanolbenzene is < 1~3.99 (at 1 mg/L) and < 1~2.08 (at 10 mg/L). The bioconcentration factor of meta-Diisopropanolbenzene in fish was below 100, so the test substance has low bioconcentration effect on fish during the exposure period of 28 days.
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