Ammonium manganese(3+) diphosphate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Ammonium manganese(3+) diphosphate

EC Number:

233-257-4

EC Name:

Ammonium manganese(3+) diphosphate

Cas Number:

10101-66-3

Molecular formula:

MnKx (NH4)1-x P2O7 (0 =< x =< 0.5)

IUPAC Name:

Ammonium manganese diphosphate, monoclinic and triclinic

Details on test material:

Lot X-1426

Test animals

Species:

rat

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200-300 g
- Fasting period before study: yes, fasted for 24 h

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

propylene glycol

Doses:

4000, 8000, 10000, 12500, 16000, 20000 and 32000 mg/kg

No. of animals per sex per dose:

Five animals per dose

Control animals:

no

Details on study design:

- Duration of observation period following administration: Two weeks
- Frequency of observations: Animals were observed daily.
- Necropsy of survivors performed: No postmortem, or histopathology examinations were performed in this particular study.

Results and discussion

Effect levels

Effect levels 1

Key result

Dose descriptor:

LD50

Effect level:

12 900 mg/kg bw

Based on:

test mat.

95% CL:

11 500 - 14 400

Effect levels 2

Dose descriptor:

LD0

Effect level:

10 000 mg/kg bw

Based on:

test mat.

Clinical signs:

other: Ruffled, unkempt coats were evident at 4000 mg/kg. Lethargy, unkempt coats and nasal hemorrhage were prevalent in the animals dosed at 8000 mg/kg and 10000 mg/kg. Staggering gait, impaired locomotion, lethargy and nasal hemorrhage were noted at levels of

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The oral LD50 was determined to be 12900 mg/kg.

Executive summary:

An acute oral toxicity was performed using albino male and female rats. The oral LD50 was determined to be 12900 mg/kg (95% confidence limits = 11500 -14400 mg/kg).