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EC number: 268-215-4
CAS number: 68037-92-3
This substance is identified by SDA Substance Name: C16-C22 alkyl amine and SDA Reporting Number: 21-029-00.
The toxicity of C16-22-(even numbered) alkylamines to Daphnia magna was determined in an OECD 202 GLP study. The EC50 (48h) was established to 1.92 mg/L.
The toxicity of C16 -22 -(even
numered) alkylamines to Daphnia magna was determined accordning to an
OECD 202 test. The study was conducted under semi-static conditions
over a period of 48 h with 5 concentrations of the test item
C16-22-(even numbered)-alkylaminesin natural river water ranging from
0.500 to 8.00 mg/L set up in a geometric series with a dilution factor
of 2. Twenty daphnids were exposed to each concentration level and the
control. The concentrations of the C18- and C22-fraction of the test
verified by LC-MS/MS in the fresh media (0 and 24 h) and in the old
media (24 and 48 h) of all concentration levels and the control.
The test item C16-22-(evennumbered)-alkylamineshas
a low water solubility and sorbs to organic an inorganic materials by
different mechanisms. The sorption processes are mostly non-linear,
means are concentration dependent. Due to these properties the test
item is difficult to test in synthetic water (e.g. sorption to the
test organisms and glass walls of the test vessels) and results from
such tests depend from the test settings applied. Using natural river
water which contains particulate as well as dissolved organic carbon
to which the test item can sorb partially reduces the difficulties
encountered in tests with synthetic water (e.g. preventing that the
test item settles onto surfaces). The sorbed fraction of the test item
is difficult to extract from the test system which normally leads to
low analytical recoveries. It was confirmed by measurements that only
6 – 11 % of the test item at a concentration of 2 mg/L nominal sorb to
the glassware (see also below). This concentration of 2 mg/L nominal
is close to the calculated EC50(48 h). That means that the
test item is present in the test system and therefore available for
exposure (dissolved in water and sorbed).Due to the
properties of the test item the nominal concentrations were used for
assessment of the endpoints instead of measured ones.
The recoveries of the C18-fraction
were in the range of 38 to 90 % of the nominal values in the fresh
media (0 and 24 h) and 2 to 60 % in the old media (24 and 48 h).
Recoveries of the C22-fraction were in the range of 68 to 100 % of the
nominal values in the fresh media (0 and 24 h) and 2 to 74 % in the
old media (24 and 48 h).
quality parameters (pH-value and dissolved oxygen concentration),
measured at 0, 24 and 48 h, were determined to be within the
acceptable limits. The validity criteria of the test guideline were
EC50- (with Confidence Interval), EC100- Values,
NOEC and LOEC
on the nominal test item concentrations ofC16-22-(evennumbered)-alkylamines)
(with 95 % confidence limits)
Nominal Concentration of the Test Item
2.84 (CI: – 3.45)
1.72 (CI: 1.68 – 1.75)
6.42 (CI: 5.83 – 6.88)
1.92 (CI: 1.89 – 1.94)
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