N-(2-nitrophenyl)phosphoric triamide

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

other: expert statement

Adequacy of study:

supporting study

Study period:

2013-11-08

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

other: expert statement

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Objective of study:

toxicokinetics

Test guideline

Qualifier:

no guideline available

Guideline:

other: none

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

477-690-9

EC Name:

-

Cas Number:

874819-71-3

Molecular formula:

Hill formula: C6H9N4O3P CAS formula: C6H9N4O3P

IUPAC Name:

N-(diaminophosphoryl)-2-nitroaniline

Test material form:

solid: crystalline

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): no data
Since no toxicokinetic studies are available for 2-NPT the assessment of the toxicokinetic behavior is based on the physico-chemical properties of the substance.
The oral absorption of 2-NPT is set at 100 %.

For 2-NPT, no transport through the skin could be detected in an dermal absorption study according to OECD Guideline 428. Therefore, only a limit value < 6E-9 cm∙s-1could be estimated. The maximum absorbed quantity into the skin was 0.92 µg.cm-2for 2–NPT after 24 hours contact with the skin. This corresponds to 0.26 % of the applied dose 2-NPT.
Based on these results, it can be stated that there will be a negligible transport of 2-NPT into or through human skin, especially as the real life exposure levels are half of the used ones.
After deposition water soluble particles of 2-NPT may readily diffuse/dissolve into the mucus lining of the nasopharyngeal region and may then be dermally absorbed. After absorption 2-NPT is expected to distribute easily throughout the body based on its low molecular weight, the log Pow > 0 (some lipophilicity) and the high water solubility. Since the log Pow of 2-NPT is < 4 the substance is not expected to accumulate within the body. Once absorbed, the mammalian organism may metabolize the substance 2-NPT by hydroxylation of appropriate carbon and nitrogen atoms which may be followed by conjugation. Based on the water solubility and the low molecular weight the unchanged molecule and the metabolites are expected to be predominantly excreted renally via urine.

Executive summary:

Since no toxicokinetic studies are available for 2-NPT the assessment of the toxicokinetic behavior is based on the physico-chemical properties of the substance. The oral absorption of 2-NPT is set at 100 %. Also 100 % dermal absorption is proposed for 2-NPT.

For 2-NPT, no transport through the skin could be detected in an dermal absorption study according to OECD Guideline 428. Therefore, only a limit value

After deposition water soluble particles of 2-NPT may readily diffuse/dissolve into the mucus lining of the nasopharyngeal region and may then be dermally absorbed. After absorption 2-NPT is expected to distribute easily throughout the body based on its low molecular weight, the log Pow > 0 (some lipophilicity) and the high water solubility. Since the log Pow of 2-NPT is < 4 the substance is not expected to accumulate within the body. Once absorbed, the mammalian organism may metabolize the substance 2-NPT by hydroxylation of appropriate carbon and nitrogen atoms which may be followed by conjugation. Based on the water solubility and the low molecular weight the unchanged molecule and the metabolites are expected to be predominantly excreted renally via urine.