Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 254-075-1 | CAS number: 38668-48-3
Nature and duration of local clinical signs in male animals
Erythema grade 1
d5 – d9
d5 – d6
d2 - d5
d1 - d5
Erythema grade 2
d1 – d2
Edema grade 1
Edema grade 2
Nature and duration of local clinical signs in female animals
Erythema grade 3
d5 – d8
Local effects in male animals
In four male animals well-defined erythema (grade 2) was noted on study day 1, persisted in three of these animals until study day 2 and decreased to very slight erythema (grade 1) on study day 5. This grade persisted up to study day 6 (one animal) or 9 (two animals).
In the fourth of these animals well-defined erythema decreased to very slight and was already seen on study day 2 and persisted until study day 5 after administration. Very slight erythema was seen in the fifth male from study day 1 until study day 5. On study day 1 slight edema (grade 2) was noted in four animals and persisted in three males until day 2. In the fourth male edema decreased to very slight (grade 1) on day 2. In the fifth male very slight edema was observed from study day 1 until day 2. Furthermore incrustations and scaling were noted from study day 5 until study day 8 or 9 in two males, each.
Local effects in female animals
Very slight erythema (grade 1) was noted in one animal on study day 1, while in three others well-defined erythema (grade 2) was noted on study day 1, persisted in one of these animals until study day 2 and decreased to very slight on study day 5. In the other two females very slight erythema was noted on study day 2. Moderated erythema (grade 3) was seen in the fifth animals on study day 1, but decreased step-wise from well-defined erythema on study day 2 to very slight erythema on study day 5. Very slight edema (grade 1) was observed in all females on study day 1 and persisted in one out of these animals until day 2. Furthermore scaling was noted in one female animal from study day 5 until study day 8.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again