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EC number: 203-988-3 | CAS number: 112-59-4
The LD50 values (with 95% confidence limits) were 2.14 ml/kg (1.45 - 3.17) for males and 2.37 ml/kg (2.03 - 2.76) ml/kg for females. The slope of the dose-mortality curve was steeper for females (13.3) than males (4.96).
Undiluted test material was applied to the clipped trunk skin of groups of 5 male or female rabbits (2 to 3 kg) at the following concentrations: 1, 2 or 4 ml/kg (males), and 1, 2, 2.8 or 4 ml/kg (females). An occlusive dressing consisting of polyethylene sheeting, adhesive tape and plastic ties was used to keep the material in contact with the skin. Animals were immobilized during the 24 hour contact period. Test material was then removed with moist tissue. Animals were examined twice daily for 14 days for signs of local irritation and systemic toxicity. Body weights were taken before dosing and 7 and 14 days following dosing. Necropsies were performed on animals that died and all animals surviving the 14 day observation period. LD50 values and their slopes werecalculated by the moving average method. All animals treated with 2.8 or 4.0 ml/kg died within 6 days of exposure.Two out of five male rats dosed with 2.0 ml/kg died within 2 days. None of the females treated with 2.0 ml/kg died. There were no deaths in males or females treated with 1 ml/kg. Animals that died had dark red or pink lungs. These effects were also noted in some of the animals that survived (doses, sex and number not stated). Signs of toxicity included salivation, sluggishness, unsteady gait and comatose appearance. These signs occurred during exposure and survivors recovered within 3 to 4 days. Females treated with 2.0 ml/kg lost weight over the first week of recovery but then recovered. Erythema, edema, necrosis and ecchymoses were found at the application site up to study termination (doses not stated). The LD50 values (with 95% confidence limits) were 2.14 ml/kg (1.45 - 3.17) for males and 2.37 ml/kg (2.03 - 2.76) ml/kg for females. The slope of the dose-mortality curve was steeper for females (13.3) than males (4.96).
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