Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

basic toxicokinetics, other
read-across from a variety of sources
Type of information:
other: review
Adequacy of study:
weight of evidence
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
read-across from a variety of sources

Data source

Reference Type:
review article or handbook

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Details on test material:
- Other: members of the substance class glycol ethers, e.g. ethylene glycol methyl ether, ethylene glycol ethyl ether, ethylene glycol butyl ether, diethylene glycol butylene ether

Test animals

other: review, several studies
not specified
Details on test animals or test system and environmental conditions:

Administration / exposure

Route of administration:
other: several, data review
not specified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Glycol ethers and their acetates are readily absorbed following oral administration or inhalation. Dermal absorption is also an important route.
Details on distribution in tissues:
Glycol ethers are readily distributed throughout the body - no substantial accumulation of the parent compound has been observed. In contrast to the metabolites of ethlene glycol methyl ether and ethylene glycol ethyl ether, the metabolite of ethylene glycol butylene ether shows no evidence of significant accumulation.

Any other information on results incl. tables

In the metabolism of the longer chain ethylene glycol ethers (ethylene glycol butyl ether, -propyl ether, -isopropyl ether and -phenyl ether), methoxyacetic and ethoxyacetic acid are not formed.

The alkoxyacetic acid metabolites, methoxyacetic acid and ethoxyacetic acid, have been found to be responsible for bone marrow depression, testicular atrophy, developmental toxicity, and immunotoxicity in animals treated with methyl- and ethyl-substituted ethylene glycol ethers. As these metabolites are not formed in the metabolism of the longer chain ethylene glycol ethers (ethylene glycol butyl ether, -propyl ether, -isopropyl ether and -phenyl ether) these materials do not cause the described effects.

Applicant's summary and conclusion