Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-988-3 | CAS number: 112-59-4
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- read-across from a variety of sources
- Type of information:
- other: review
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- read-across from a variety of sources
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 005
Materials and methods
- GLP compliance:
- not specified
Test material
- Details on test material:
- - Other: members of the substance class glycol ethers, e.g. ethylene glycol methyl ether, ethylene glycol ethyl ether, ethylene glycol butyl ether, diethylene glycol butylene ether
Constituent 1
Test animals
- Species:
- other: review, several studies
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- n/a
Administration / exposure
- Route of administration:
- other: several, data review
- Vehicle:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Glycol ethers and their acetates are readily absorbed following oral administration or inhalation. Dermal absorption is also an important route.
- Details on distribution in tissues:
- Glycol ethers are readily distributed throughout the body - no substantial accumulation of the parent compound has been observed. In contrast to the metabolites of ethlene glycol methyl ether and ethylene glycol ethyl ether, the metabolite of ethylene glycol butylene ether shows no evidence of significant accumulation.
Any other information on results incl. tables
In the metabolism of the longer chain ethylene glycol ethers (ethylene glycol butyl ether, -propyl ether, -isopropyl ether and -phenyl ether), methoxyacetic and ethoxyacetic acid are not formed.
The alkoxyacetic acid metabolites, methoxyacetic acid and ethoxyacetic acid, have been found to be responsible for bone marrow depression, testicular atrophy, developmental toxicity, and immunotoxicity in animals treated with methyl- and ethyl-substituted ethylene glycol ethers. As these metabolites are not formed in the metabolism of the longer chain ethylene glycol ethers (ethylene glycol butyl ether, -propyl ether, -isopropyl ether and -phenyl ether) these materials do not cause the described effects.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
