Registration Dossier
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EC number: 203-988-3 | CAS number: 112-59-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Althought the study methodology followed OECD TG 203, EPA OTS 797.1400 and ASTM guidelines, it is unclear whether the study was conducted as per Good Laboratory Practices (GLP) and the report contains no information on analytical measurements of the tested doses.
- Qualifier:
- according to
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- Qualifier:
- according to
- Guideline:
- EPA OTS 797.1400 (Fish Acute Toxicity Test)
- Deviations:
- not specified
- Qualifier:
- according to
- Guideline:
- other: Annual Book of ASTM Standards, Water and Environmental Technology, Vol. 11.05, (1995)
- Deviations:
- not specified
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Hexyl Carbitol Solvent
- Physical state: liquid - Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- Dechlorinated Charleston municipal water was used in tests as dilution water and in experimental controls and the same water was used for maintaining the in-house fathead minnow stock. The incoming water was treated with activated carbon in a two-gallon filter yielding a chlorine-free dilution water with a pH very close to 7.0. The carbon beds were changed as needed to maintain water quality.
- Test organisms (species):
- Pimephales sp.
- Details on test organisms:
- TEST ORGANISM
- Common name: fathead minnows
- Strain: no information available
- Source: in-house stock (UCC laboratory culturing program)
- Age at study initiation (mean and range, SD): 21-60 days
- Length at study initiation (length definition, mean, range and SD): average fish length ranged from 10-15 mm
- Weight at study initiation (mean and range, SD): average wet weight/fish ranged from 10-25 grams
- Other: organism loading ranged from 0.13-0.33 g wet-weight fish/dose - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 40 to 60 mg/L as CaCO3 (measured)
- Test temperature:
- no information available
- pH:
- close to 7.0
- Dissolved oxygen:
- no information available
- Nominal and measured concentrations:
- - Nominal concentrations: no information available.
- Details on test conditions:
- A minimum of 5 concentrations of each test substance were utilized, with each 1.5 liter volume containing 20 fish fry. Fish survival and physical response, as well as temperature, pH and dissolved oxygen levels, were monitored daily during the test period of 96 hours.
- Reference substance (positive control):
- not required
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 200 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL -180-210 mg/L
- Reported statistics and error estimates:
- The concentration of test product which affected 50% of the test population was calculated for the 96-hour exposure period by the Spearman-Karber estimator. The 95% confidence intervals were also provided by this program.
Reference
ADDITIONAL REPORTED EFFECT CONCENTRATIONS
96-h NOEC = 95 mg/L
Description of key information
DGHE is with high probability acutely not harmful to fish.
The 96-h LC50 value is 200 mg/L in freshwater fish (Pimephales sp.)
Key value for chemical safety assessment
Additional information
The short-term toxicity to freshwater fish was determined in a study according to OECD TG 203. In this study, groups of 20 Pimephales sp. were exposed for 96 hours to five concentrations of test substance under static conditions. No analytical verification of the test material performed. The 96-hour LC50 of the test material was calculated to be 200 mg/L (95% fiducial limits ranging between 180-210 mg/L).
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