Registration Dossier

Administrative data

Endpoint:
repeated dose toxicity: inhalation
Type of information:
other: Publication
Adequacy of study:
supporting study
Study period:
1966
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
publication
Title:
Chronic Inhalation Toxicity of CHLOROBROMOMETHANE
Author:
MacEwen, James D.; McNerney, James M.; Vernot, Edmond H.; Harper, David T.
Year:
1966
Bibliographic source:
J. Occupational Med. (1966), 8(5), 251-6

Materials and methods

GLP compliance:
not specified

Test animals

Species:
dog
Strain:
Beagle

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
Daily inhalation exposure of. CH2ClBr 30 hrs. weekly for 6 months at levels of 500 and 1000 ppm.
Duration of treatment / exposure:
30 hrs. weekly for 6 months
Frequency of treatment:
Daily

Results and discussion

Results of examinations

Details on results:
Serum bromide ion concentration in dogs and rats were above 95mg% in the exposed animals.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion

Conclusions:
It may concluded that the current ACGIH threshold limit value of 200 ppm for CHLOROBROMOMETHANE.
This limit is a satisfactory working level for chronic daily exposure.