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EC number: 212-146-4 | CAS number: 765-43-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Cyclopropyl methyl ketone
- EC Number:
- 212-146-4
- EC Name:
- Cyclopropyl methyl ketone
- Cas Number:
- 765-43-5
- Molecular formula:
- C5H8O
- IUPAC Name:
- 1-cyclopropylethan-1-one
- Test material form:
- other: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: healthy, young adult animals
- Fasting period before study: 16 hours. 3 hours after application food was offered ad libitum.
- Housing:max. 5 animals/cage
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 3°C
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 08.09.1997 To: 23.10.1997
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- In the first step three male rats were given a single oral application of the test substance at a limit-dose of 2000 mg/kg bodyweight. No rats died after the treatment, so three female rats were treated in the same way. Since mortalities occurred in two females, three male rats were treated with the dose
level of 200 mg/kg bw. No mortalities were observed in the animals after administration of this dose. Therefore three female rats were treated in the
same way.
The dosing formulation was applied to the rats by gavage using a stomach tube (2.23 cm3/kg for 2000mg/kg and 0.22 cm3/kg for 200 mg/kg bodyweight). - Doses:
- 200 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: soon after dosing and 1, 2, 3, 4, 5 and 6 h after dosing and once daily thereafter
- Frequency of weighing: day 0 (prior to dosing), day 7, day 14 or after death of an animal
- Necropsy of survivors performed: yes
- Other examinations performed: gross examination of organs at necropsy
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2000 mg/kg bw: 0/3 male animals, 2/3 female animals
200 mg/kg bw: 0/3 male animals, 0/3 female animals
500 mg/kg bw: 0/3 male animals, 0/3 female animals - Clinical signs:
- other: Male animals dosed with 2000 mg/kg bw, showed moderate to severe clinical signs on the day of treatment. Half an hour until 6 hours p.a. signs like sedation, abdormal and lateral position, paddling movements, vocalisation, difficult and hurried breathing,
- Gross pathology:
- The macroscopical examination of the deceased two female animals dosed with 2000 mg/kg bw revealed autolytic changes of all tissues. The surviving female showed agglutinations of tissues of the addominal cavity (liver, spleen, pancreas and stomach).
All male animals dosed with 2000 mg/kg bw and all male/female animals dosed with 200 mg/kg bw showed no macroscopical abnormalities.
Any other information on results incl. tables
Amendment to the final report:
In an amendment to the final report an experiment with the dose group 500 mg/kg bw was reported.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- In this oral toxicity study in the rat an LD50 between 500 and 2000 mg/kg bw was found for the test item.
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