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Diss Factsheets
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EC number: 500-687-1 | CAS number: 162303-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Testing is not scientifically justified as this substance is hydrolytically unstable. Therefore, the read-across result of the 16-h toxicity threshold of n-butanol to Pseudomonas putida (cell multiplication) based on the nominal concentrations is used as key value in CSA.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 650 mg/L
Additional information
As the target substance hydrolyses rapidly (half-life <2 hours), the toxicity to microorganisms is related to the main organic degradation product (n-butanol) of the target substance. Therefore, it was justified to use the toxicity of the main decomposition product as a key value in CSA.
Based on the biodegradability of n-butanol as measured in a 20-d BOD assay using unacclimated sewage seed of 68 % ThOD in 5 days, 87 % BOD in 10 days, and 92 % after 15 days, n-butanol is expected to be easily biodegraded in municipal sewage treatment plants outfitted with at least secondary treatment (i.e., biological treatment). Based on the aqueous solubility (63 200 mg/l), negligible accumulation onto sewage sludge particles is expected. Based on this study by Price et al. (1974) it can be concluded that n-butanol released from the target substance has no inhibitory effects on activated sludge.
According to the ECHA Guidance on information requirements and chemical safety assessment, in absence of activated respiration test, toxicity results to microbial bacteria can be used for evaluate the inhibitory effects of chemicals to STP micro-organisms. Therefore, the result of the P.putida cell multiplication inhibition test of the organic hydrolyzing product (n-butanol) is used to calculate the PNEC STP (Bringmann & Kuhn 1980).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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