Registration Dossier
Registration Dossier
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EC number: 205-498-5 | CAS number: 141-75-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: BASF-Test: Animals were treated for 3 minutes and 4 hours using occlusive conditions. An application site of 2.5x2.5 cm was covered with the liquid test substance. After the application time the skin was washed clean with Lutrol (50%). The animals were observed for 8 days and skin changes were recorded daily. The report describes findings at 4 hours, days 1, 2 and 8 post exposure.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyryl chloride
- EC Number:
- 205-498-5
- EC Name:
- Butyryl chloride
- Cas Number:
- 141-75-3
- Molecular formula:
- C4H7ClO
- IUPAC Name:
- butanoyl chloride
- Details on test material:
- - Name of test material (as cited in study report): n-büttersäurechlorid
- Substance number: XXVI 622
- Substance type: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 4-hour exposure: 2.82 kg (mean); 3-minute exposure: 2.95 kg (mean)
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- 3 minutes and 4 hours
- Observation period:
- 4 hours, 1, 2 and 8 days after the treatment was finished
- Number of animals:
- 2/exposure duration
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm (patch test)
REMOVAL OF TEST SUBSTANCE
- Washing: with Lutrol (50%)
- Time after start of exposure: 3 minutes and 4 hours
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- - application for 3 minutes
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: the score at 4 hours was 3 and at 8 days the score was 4; necrosis was observed at all time points
- Irritation parameter:
- edema score
- Remarks:
- - application for 3 minutes
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: the score at 4 hours was 1 and at 8 days the score was 2; necrosis was observed at all time points
- Irritation parameter:
- erythema score
- Remarks:
- - application for 4 hours
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: score at 4 hours and day 8 was 4; necrosis was observed at all time points
- Irritation parameter:
- edema score
- Remarks:
- - application for 4 hours
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: the score at 4 hours was 2 and at day 8 the score was 2.5; necrosis was observed at all time points
Any other information on results incl. tables
4 hours application:
Animal No. |
4 hours |
|
24 hours |
|
48 hours |
|
8 days |
|
|
erythema |
edema |
erythema |
edema |
erythema |
edema |
erythema |
edema |
1 |
4 Nw ü |
2 |
4 Nw ü |
2 |
4 Nw ü |
2 |
4 Nl |
2 |
2 |
4 Nw ü |
2 |
4 Nw ü |
2 ü |
4 N ü |
2 |
4 Np |
3 |
N: necrosis w: soft; p: pergamentous; l: lether-like
ü: overlapping
3 min application:
Animal No. |
4 hours |
|
24 hours |
|
48 hours |
|
8 days |
|
|
erythema |
edema |
erythema |
edema |
erythema |
edema |
erythema |
edema |
1 |
4 N |
2 |
4 N ü |
3 ü |
4 N ü |
3 ü |
4 Np |
2 |
2 |
2 |
0 |
4 Np |
3 ü |
4 N ü |
3 ü |
4 Np |
2 |
N: necrosis p: pergamentous
ü: overlapping
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
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