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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Description of key information

Parent compound butyryl chloride: With high probability acutely not harmful to aquatic organisms.
Hydrolysis product butyric acid: With high probability acutely not harmful to aquatic organisms.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Dose descriptor:
LC50
Effect concentration:
> 464 mg/L

Additional information

QSAR-disclaimer

In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

For the assessment of N-(2-aminoethyl)-1,3-propanediamine (Q)SAR results were additionally used for the estimation of the short-term toxicity to fish. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

Therefore, and for reasons of animal welfare additional experimental studies on aquatic toxicity are not provided

 

Assessment

In aquatic systems, butyryl chloride (CAS 141-75-3) hydrolyses quickly and forms HCl (CAS 7647-01-0) and butyric acid (CAS 107-92-6) (for details see section 5.1.2).

 

Parent compound butyryl chloride (141-75-3)

The acute toxicity of butyryl chloride to fish was determined according to OECD TG 203 with Danio rerio, with analytical verified test concentrations. However, butyryl chloride hydrolyses rapidly, therefore the fish were presumably mainly exposed to the hydrolysis products butyric acid and hydrochloric acid. The obtained 96h LC50 was 299 mg/L. When tested under neutralised conditions (pH-adjusted), the LC50 was > 464 mg/L (BASF, 1998; 10F0451/965162). Based on the available data, the substance is assessed to be with high probability acutely not harmful to fish.

 

Hydrolysis product butyric acid (CAS 107-92-6) 

The toxicity of butyric acid to fish was evaluated by a QSAR calculation with KATE2020, which estimated a 96 h LC50 of 340 mg/L (BASF SE, 2022). The substance is within the applicability domain of the model. Based on the available data, the substance is with high probability acutely not harmful to fish. 

 

Isobutyric acid (CAS 79-31-2):

The toxicity of isobutyric acid to fish was evaluated by a QSAR calculation with KATE2020, which estimated a 96 h LC50 of 370 mg/L (BASF SE, 2022). The substance is within the applicability domain of the model. Based on the available data, the substance is with high probability acutely not harmful to fish.