.beta.-D-Ribofuranose, 5-deoxy-, 1,2,3-triacetate

Oxidising properties

Administrative data

Endpoint:

oxidising solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 October 2012 to 20 February 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Fully GLP compliant and in accordance with current test guidelines

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2014

Report date:

2014

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.17 (Oxidising Properties (Solids))

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Acetylfuranoside

IUPAC Name:

Acetylfuranoside

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Details on test material:

Name: Acetylfuranoside
Physical state: White crystalline powder
Batch number: 201203272009
Purity: 98.7%
Arrival date: 26 October 2012
Expiry date: 31 March 2013
Storage details: Room temperature (15 to 30°C)

Study design

Contact with:

powdered cellulose

Duration of test (contact time):

5 min

Results and discussion

Test results (Oxidising solids)

Test results (Oxidising solids) 1

Sample tested:

reference mixture (not specified)

Remarks:

migrated information

Parameter:

maximum burning rate

Result:

0.73 other: mm/s (migrated information)

Test results (Oxidising solids) 2

Sample tested:

test mixture (not specified)

Remarks:

migrated information

Parameter:

maximum burning rate

Result:

1.4 other: mm/s (migrated information)

Any other information on results incl. tables

Preliminary test:

The Acetylfuranoside/cellulose mixture ignited with an orange flame, burning for ca 5 minutes. No vigorous reaction was observed. When examined after flame extinction, unburned solide test substance was observed in the centre of the cone. It was therefore necessary to perform the full train test.

Train test:

The burning rates of the test substance mixtures at 40%, 50% and 60% were higher than that of the reference substance. The maximum burning rate for the Acetylfuranoside/cellulose mixtures was 1.40 mm/sec at 50% test substance, which compared with 0.73 mm/sec for the 60% reference substance mixture[1]. The flame propagated only across the surface of the train.

This suggested Acetylfuranoside may be oxidising and further evaluation was required. The burning rate of the reference mixture was noted to be low (target 1 mm/sec) but is not unusual relative to other recent experiments at Smithers Viscient.

False positive test:

The mixtures at 10, 20, 30 and 90% Acetylfuranoside failed to ignite.

For the mixture at 80% burning occurred along the outside edge of the train with a burning rate of 2.38 mm/sec. After propagating 200 mm the train continued to burn until most of it was charred.

The burning rates in the presence of kieselguhr were higher than those of any mixtures containing cellulose. This indicates that Acetylfuranoside cannot be oxidising because an oxidising material would burn slower in the presence of kieselguhr.

The burning characteristics recorded throughout the test are not indicative of oxidation.

The calculated oxygen balance does not indicate that Acetylfuranoside is likely to be oxidising.

It is therefore concluded, that the high burning rates seen in the presence of cellulose are attributable to true burning and not oxidising. Acetylfuranoside is not considered to be oxidising.

[1]The original result for the reference mixture was 0.37 mm/sec which is noted to be low versus the traditional target of 1 mm/sec but is not atypical in this laboratory. A further check was made using freshly prepared barium nitrate which gave a result of 0.73 mm/sec. This is not considered to have affected the results of the test.

Applicant's summary and conclusion

Interpretation of results:

other: no oxidising properties

Remarks:

Migrated information

Conclusions:

It is concluded, that the high burning rates seen in the presence of cellulose are attributable to true burning and not oxidising. Acetylfuranoside is not considered to be oxidising.

Executive summary:

The oxidising properties of Acetylfuranoside were measured in accordance with EC Directive 92/69/EEC Method A17. It was established that Acetylfuranoside was not oxidising.