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EC number: 231-679-3 | CAS number: 7681-82-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from a publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of Excess Dietary Iodine upon Rabbits, Hamsters, Rats and Swine.
- Author:
- R. Arrington, R. N. Taylor, Jr., C. H. Ammerman AndR. L. Shirley
- Year:
- 1 965
- Bibliographic source:
- Journal of Nutrition; vol. 87, no. 4, pg. 394-398; December 1, 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 414: Pre-Natal Developmental toxicity screening test.
- Principles of method if other than guideline:
- The above experiment was performed to assess and evaluate the effects of the test chemical on Long-Evans rats.
- GLP compliance:
- not specified
- Limit test:
- no
- Justification for study design:
- No Data Available
Test material
- Reference substance name:
- Sodium iodide
- EC Number:
- 231-679-3
- EC Name:
- Sodium iodide
- Cas Number:
- 7681-82-5
- Molecular formula:
- INa
- IUPAC Name:
- sodium iodide
- Test material form:
- solid: crystalline
- Details on test material:
- Details on test material
- Name of test material (as cited in study report):Sodium iodide
- Molecular formula (if other than submission substance):INa
- Molecular weight (if other than submission substance):149.89427
- Substance type:Inorganic
- Physical state:Solid
- Impurities (identity and concentrations):N/A
Constituent 1
- Specific details on test material used for the study:
- - Molecular weight (if other than submission substance): 149.89427 g/mol
- Substance type: Inorganic
- Physical state: Solid
- Impurities (identity and concentrations): N/A
Test animals
- Species:
- rat
- Strain:
- Long-Evans
- Details on species / strain selection:
- No Data Available
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Housing: Animals were housed individually in wire cages. Prior to littering, rats were transferred to 3 X 3 mesh wire cages.
- Diet (e.g. ad libitum): Purina Laboratory Chow were provided ad libitum
- Water (e.g. ad libitum): Tap water was supplied ad libitum
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: Diet as Purina Laboratory Chow
- Details on exposure:
- Details on exposure
PREPARATION OF DOSING SOLUTIONS: The test chemical was administered through diet.
DIET PREPARATION
- Rate of preparation of diet (frequency): Daily
- Mixing appropriate amounts with (Type of food): No Data Available
- Storage temperature of food: No Data Available
VEHICLE
- Justification for use and choice of vehicle (if other than water): The test chemical was best miscible in corn oil.
- Concentration in vehicle: 0, 2500 ppm (150 mg/kg bw)
- Amount of vehicle (if gavage): No Data Available
- Lot/batch no. (if required): No Data Available
- Purity: No Data Available - Details on mating procedure:
- - The sexually mature females were bred to normal males of the breed or strain. Monogamous pairs of rats were mated. When breeding occurred, the time of first copulation was recorded and gestation subsequently calculated from this time to birth of the first young of the litter. Fourteen female rats which had been fed the test chemical and had produced but lost all young in one or more litters were subsequently re-bred after removal from dietary iodine.
- After successful mating each pregnant female was caged (how): Individually - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No Data Available
- Duration of treatment / exposure:
- 12 days
- Frequency of treatment:
- Daily
- Details on study schedule:
- No Data Available
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 and 150 mg/kg bw (2500 ppm)
Basis:
Nominal in diet
- No. of animals per sex per dose:
- 27 female rats were used
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - F1 parental animals not mated until weeks after selected from the F1 litters: No Data Available
- Selection of parents from F1 generation when pups were [...] days of age: No Data Available
- Age at mating of the mated animals in the study: No Data Available - Positive control:
- No Data Available
Examinations
- Parental animals: Observations and examinations:
- Observations were made for length of parturition time and number of young born dead and those born live. Periodic observations were made through the lactation period for mothering instinct, evidence of lactation .
- Oestrous cyclicity (parental animals):
- No Data Available
- Sperm parameters (parental animals):
- No Data Available
- Litter observations:
- Survival of young animals was observed.
- Postmortem examinations (parental animals):
- No Data Available
- Postmortem examinations (offspring):
- No Data Available
- Statistics:
- The data was subjected to statistical analysis. The analytical methods included Analysis of Variance (ANOVA).
- Reproductive indices:
- No Data Available
- Offspring viability indices:
- Pups Viability Index.
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- effects observed, treatment-related
- Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- Voluntary feed intake of rats fed with the test chemical was about 6 to 7% less than that of control rats and this reduced feed intake
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Behaviour (functional findings):
- not specified
- Immunological findings:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Histopathological findings: non-neoplastic:
- not specified
- Histopathological findings: neoplastic:
- not specified
- Other effects:
- not specified
Reproductive function / performance (P0)
- Reproductive function: oestrous cycle:
- not specified
- Reproductive function: sperm measures:
- not specified
- Reproductive performance:
- effects observed, treatment-related
- Description (incidence and severity):
- REPRODUCTIVE PERFORMANCE: Gestation time for rats was not affected by the test chemical; however, prolonged parturition was observed in rats.No signs of the beginning of lactation were observed.
Effect levels (P0)
- Dose descriptor:
- LOAEL
- Effect level:
- 150 other: mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: Effects observed on the following parameters : Gestation time, Parturition and No signs of the beginning of lactation were observed.
Results: F1 generation
General toxicity (F1)
- Clinical signs:
- not specified
- Dermal irritation (if dermal study):
- not specified
- Mortality / viability:
- mortality observed, treatment-related
- Description (incidence and severity):
- Average mortality was slightly greater of young from those fed with the test chemical.
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Weaning weight was significantly less than that of controls.
- Food consumption and compound intake (if feeding study):
- not specified
- Food efficiency:
- not specified
- Water consumption and compound intake (if drinking water study):
- not specified
- Ophthalmological findings:
- not specified
- Haematological findings:
- not specified
- Clinical biochemistry findings:
- not specified
- Urinalysis findings:
- not specified
- Sexual maturation:
- not specified
- Organ weight findings including organ / body weight ratios:
- not specified
- Gross pathological findings:
- not specified
- Histopathological findings:
- not specified
- Other effects:
- not specified
Developmental neurotoxicity (F1)
- Behaviour (functional findings):
- not specified
Effect levels (F1)
- Dose descriptor:
- LOAEL
- Generation:
- F1
- Effect level:
- 150 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- viability
- mortality
- body weight and weight gain
- Remarks on result:
- other: Not Specified
Target system / organ toxicity (F1)
- Critical effects observed:
- not specified
- System:
- other: Not Specified
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
- Treatment related:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The LOAEL value of orally administered test chemical in Long-Evans rats was determined to be 150mg/kg bw.
- Executive summary:
A study was conducted with rats to determine the effects of intake of the test chemical. A total of 27 animals were used in this study. Females were bred to normal males, wherein the test chemical was added to the diet during the latter portion of gestation and the females were permitted to litter normally. The effect of the treatment on gestation period, lactation and survival of the young was observed. It was observed that, gestation time for rats was not affected ; however, prolonged parturition was observed in rats. In fetal parameters, average mortality was slightly greater of young from those fed with the test chemical, while the weaning weight was significantly less than that of controls. In other experiment, the female rats were re-bred after removal of dietary intake of the test chemical. It was observed that the females gave birth and nursed litters normally. Thus, from all the oabove observations, LOAEL was found to be 150 mg/kg bw and it is likely to be regarded that there is no reproductive toxicity at concentrations lower than 150 mg/kg bw when administered orally.
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