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EC number: 204-001-9 | CAS number: 112-73-2
The reproduction toxicity of DEGDBE was investigated according to OECD 421. In order to compensate the potentially reduced statistical power due to the reduced number of pregnant animals in all groups in the main study, the results obtained in the dose-range finding study were combined for the robust evaluation.
The male wistar rats after being treated with diethyleneglycoldibutyether in corn oil for the period of 28 days at the dosage of 250, 500 and 750 mg/ kg body weight revealed treatment related changes for body weight development and food consumption at and above 500 mg/kg bw when compared to the corresponding controls. Due to the minor degree of the observed effect no toxicological meaning was attributed.
The female rats were dose administered for approximately 54 days at the same dosage. There was changes observed for body weight development and food consumption at and above 500 mg/kg bw; mortality of one female at 750 mg/kg body weight (due to assumed complication during parturition) and Reddish urine or bedding (LD 1/13, MD 4/13 and HD 8/13 females, observed only on dose application day 2) at and above 250 mg/kg bw. The reddish urine observed in LD group was considered minor due to its finding in an individual isolated female.
There was changes observed for the number of still births, % implantation loss, litter weight data, number of live male, female and total pups and viability index (%) at or above 250 mg/kg body weight. The changes observed at 250 mg/kg body weight were of minor degree and considered of no toxicological meaning.
Based on the result the NOAEL for adult males toxicity is believed to be at 750 mg/kg body weight and for females and fetal toxicity is believed to be at 250 mg/ kg body weight. .
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