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EC number: 204-001-9 | CAS number: 112-73-2
DEGDBE is not skin irritating and not eye irritating.
24 hours up to 7 days after removal of the plaster the animals showed very slight up to well-defined erythema and 48 hours up to 7 days very slight up to well-defined oedema. Additionally, the skin surface of all animals was dry-rought, and of one animal was coarse scaled, too. 14 days after adiministration all signs of irritation were reversible.
DEGDBE was tested for its skin irritaiton potential according to the OECD Guideline 404.
Based on the obtained result, DEGDBE is not skin irritating.
DEGDBE was investigated for its eye irritation potential according to OECD 405.
One hour after administration the conjuctivae of all animals showed definitely injected blood vessels. Furthermore, one animal showed definitely injected blood vessels up to a crimson red color and slight swellings 24 hours up to 72 hours after adiminstration. Diffuse areas of opacity of the cornea were observed 24 hours after adiminstration. In the fluoresceine test 24 hours after administration staining areas were observe in this animal. In addition ot these observations, clear-colorless serous eye discharge was noted in all animals. 7 days after administration all signs of irriation had disappeared.
DEGDBE is not irritating to eyes.
The skin and eye irritation potential of DEGDBE was investigated according to OECD Guideline 404 and 405 respectively. Based on the results of these studies, no classificaiton is warranted.
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