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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was conducted pre-GLP and pre-guidelines, so the report is lacking in detail. However, it was conducted at a highly reputable laboratory and was done to the state of the art at that time.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
This study was conducted as part of the 1960 acute dermal toxicity test presented in section 7.2.3. Since the exposure period (24 hours) and the covering (occlusive) used in the dermal toxicity test was more stringent than that used in a traditional OECD 404 (4 hour exposure and semi-occlusive covering), this data can be considered to be a worst-case finding.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyronitrile
EC Number:
203-700-6
EC Name:
Butyronitrile
Cas Number:
109-74-0
Molecular formula:
C4H7N
IUPAC Name:
butanenitrile

Test animals

Species:
guinea pig
Strain:
not specified
Details on test animals or test system and environmental conditions:
None provided

Test system

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
The dose used was 0.1 - 20 cc/kg
Duration of treatment / exposure:
24 hours
Observation period:
14 days
Number of animals:
7 total
Details on study design:
Skin irritation was evaluated as part of an acute dermal toxicity test.

Results and discussion

In vivo

Results
Irritation parameter:
other:
Time point:
other: 24 hours
Score:
> 0 - < 0
Remarks on result:
other: findings were not scored, but TCC requires a score value, so "0" was used
Irritant / corrosive response data:
The test article was called out as a slight skin irritant that is absorbed through the skin.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The test article was called out as a slight skin irritant that is absorbed through the skin.
Executive summary:

Skin irritation testing was done as part of a previously cited acute dermal toxicity test. As such, the test subjects were exposed to the test article for 24 hours under occlusive conditions rather than the traditional 4 hours under semi-occlusive conditions. That makes these results a "worst case". The test article was called out as a slight skin irritant that is absorbed through the skin. Note that only qualitative scoring was done. Values in this summary were added as the only apparent way to pass the TCC tool, but no numerical scoring was used in the study.