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EC number: 249-949-4
CAS number: 29911-27-1
The sensitization potential of ARCOSOLV®
DPnP was evaluated in this modified Buehler method dermal sensitization
study. A Test Group of 10 male and 10 female Hartley albino guinea pigs
was dosed topically with the test article one time per week for three
weeks for a total of three induction exposures. The duration of each
exposure was six hours. Two weeks after the last induction exposure, the
animals were challenge-dosed for detection of sensitization by topical
application of the test article to previously unexposed areas of skin. A
Naive Control-I Group of 5 male and 5 female guinea pigs was dosed with
the test article at challenge in the same manner as the Test Group and
served as an irritation control. Reactions to challenge dosing were
evaluated at approximately 24 and 48 hours after completion of exposure.
Body weights and clinical observations were recorded at randomization
(study day -1) and at study termination (study day 30).
Positive control data were not generated as
part of this study. WIL historical positive control data from a study
conducted within six months of this test were used to demonstrate the
reliability of the experimental design.
There were no deaths, test article-related
clinical findings or remarkable body weight changes during the study
period. Following challenge dosing with ARCOSOLV® DPnP, there were no
significant dermal reactions in the Test or the Naive Control Groups.
The Incidence Index for the Test Group was 0% (0/20) following challenge
Under the conditions of this study,
ARCOSOLV® DPnP was a non-sensitizer in albino guinea pigs.
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