Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-751-1 | CAS number: 99-34-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Estimation data
- Type of information:
- other: Conclusion of WoE based on SDS
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: conclusion of WoE Study
- Title:
- Weight of evidence for eye irritation of 99-34-3
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- Sustainability Support Services (Europe) AB Report
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Principle of weight of evidence as suggest by ECHA
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,5-dinitrobenzoic acid
- EC Number:
- 202-751-1
- EC Name:
- 3,5-dinitrobenzoic acid
- Cas Number:
- 99-34-3
- Molecular formula:
- C7H4N2O6
- IUPAC Name:
- 3,5-dinitrobenzoic acid
Constituent 1
Test animals / tissue source
- Species:
- human
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Remarks on result:
- other: irritating to eyes
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
On compairing the available human data from all the various safety data sheet and C& L inventory it was found that 3,5-dinitrobenzoic acid have a positive eye irritation effect based on the human data. Moreover the pH of the substance in obtained to be less then 3, which also confirms that the substance would be irritating to eyes due to its acidic nature. So, we consider this compliant to the C & L inventory for classification as eye irritation category 2.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
