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Diss Factsheets
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EC number: 232-191-3 | CAS number: 7789-80-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Potassium iodate toxic retinopathy: a report of five cases
- Author:
- Singalavanija A; Ruangvaravate N; Dulayajinda D,
- Year:
- 2 000
- Bibliographic source:
- Retina (Philadelphia, Pa.) (2000), 20(4), 378-83
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- The clinical manifestation , toxic dosage of iodate and ocular changes in humans, who has taken potassium iodate overdose were analysed
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Potassium iodate
- EC Number:
- 231-831-9
- EC Name:
- Potassium iodate
- Cas Number:
- 7758-05-6
- IUPAC Name:
- potassium iodate
- Details on test material:
- - Name of test material : Potassium iodate
- Substance type : Inorganic
- Physical state : Solid
Constituent 1
Test animals / tissue source
- Species:
- human
- Details on test animals or tissues and environmental conditions:
- - Age at study initiation : 22 years
- Weight at study initiation : 45 kg
Test system
- Vehicle:
- water
- Controls:
- no
- Observation period (in vivo):
- 3 hrs
- Details on study design:
- A 22-year-old man had drunk approximately half of the contents (approx 300 ml) of a whiskey bottle . The bottle had contained a concentrated KIO3 solution
Results and discussion
In vivo
Results
- Irritation parameter:
- other: retinal toxicity
- Time point:
- other: 3 hrs
- Remarks on result:
- other: Irritating to eyes
- Other effects:
- Nausea, vomiting and diarrhea was observed three hrs after ingestion. Two hours later he had blurred vision .Ocular examination showed a visual acuity (VA) of hand motions in both eyes. The fundi showed retinal edema with hypo pigmentation in the macular area. Fundus Fluorescein angiography(FFA) showed extensive RPE window defects in both eyes. The flash ERG showed a marked reduction in amplitude and delayed implicit time of a- and b-waves with all stimuli in both eyes. Flash VEP showed a normal latency and decreased amplitude of P100 in both eyes. Findings from urine examination and blood chemistry were normal.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- From the above case study it is concluded that potassium iodate produce retinal toxicity that damage RPE and photoreceptor cells
- Executive summary:
In a case studya 22-year-old man had drunk approximately half of the contents (approx 300 ml) of a whiskey bottle .The bottle had contained a concentrated KIO3 solution. The patient weighed 45 kg, so the approximately oral dose ingested was 187 mg/kg body weight. Three hours after ingesting the solution, he experienced nausea, vomiting and diarrhoea. Two hours later he had blurred vision that he described as “seeing in a fog." Ocular examination showed a visual acuity. The fundi showed retinal edema with hypo pigmentation in the macular area. This shows that potassium iodate produce retinal toxicity that damage RPE and photoreceptor cells.
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