Calcium iodate

Endpoint summary

Additional information

Short-term toxicity to fish

Based on the various studies available with Klimish rating 2and 4 for the target substance Calcium iodate and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC0	100 mg/l	mortality	96 hrs	Danio rerio	Study Report for target chemical
2	NOEC	100 mg/l	mortality	7 days	Danio rerio	Study Report for target chemical
3	LC50	558.5557 mg/l	mortality	96 hrs	Oncorhynchus mykiss	Predicted data for target chemical
4	LC50	350 mg/l	mortality	96 hrs	Oncorhynchus mykiss	Data from publication for CAS no 7681-55-2
5	LC50	896 mg/l	mortality	96 hrs	Oncorhynchus mykiss	Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC0 value was found to be 100 mg/l in 96 hrs study and the LC50 values was found to be in range of 350 to 896 mg/l in 96 hrs on the basis of mortality effect . Thus according to CLP criteria of aquatic classification it is concluded that the substance Calcium iodate is not toxic to Fish (Danio rerio, Oncorhynchus mykiss)

Long-term toxicity to fish

According to annex IX of column I ; Long-term toxicity testing on fish need not to be conducted as it is already provided as a part of Annex VII requirements.Therefore this study was considered to be waived.

Short-term toxicity to aquatic invertebrates

Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	LC50	236.1352 mg/l	mortality	48 hrs	Daphnia magna	Predicted data for target chemical
2	LC50	226 mg/L.	mortality	24 hrs	Dreissena polymorpha	Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 226 to 236.1352 mg/l in a 24 to 48 hrs study on the basis of mortality effect . Thus according to CLP criteria of aquatic classification it is concluded that the substance calcium iodate is not toxic to aquatic invertebrate (Daphnia magna and Dreissena polymorpha)

Long-term toxicity to aquatic invertebrates

According to annex IX of column I; Long-term toxicity testing on invertebrate (species: Daphnia) need not to be conducted as it is already provided as a part of Annex VII requirements.Therefore this study was considered waived.

Toxicity to aquatic algae and cyanobacteria

Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	MIC	843.1238 mg/l	growth rate	10 days	Dunaliella salina	Predicted data for target chemical
2	MIC	1124.559 mg/l	growth rate	10 days	Cryptomonas sp.	Predicted data for target chemical
3	MIC	2600.4mg/l	growth rate	10 days	N. closterium	Data from publication for CAS no 7681-11-0
4	MIC	2590.7mg/l	growth rate	10 days	Phaedactylum tricornutum	Data from publication for CAS no 7681-11-0
5	MIC	696.2mg/l	growth rate	10 days	Chlorella sp.	Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that MIC (Minimum Inhibitory Concentration) value is expected to be in range of696.2 to2600.4 mg/l. Thus considering CLP Criteria for aquatic classification of the substance, it is concluded that Calcium iodate does not exhibit toxicity to green algae (Dunaliella salina, Cryptomonas sp,  N. closterium, Phaedactylum tricornutum, Chlorella sp.)

Toxicity to microorganisms

Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Basis for effects	Duration	Species	Remarks
1	MIC	509.603 mg/l	growth inhibition	24 hrs	Clostridium sp.	Predicted data for target chemical
2	MIC	518.4457 mg/l	growth inhibition	24 hrs	Escherichia coli (JKE029)	Predicted data for target chemical
3	MIC	358.3 mg/l	growth inhibition	24 hrs	Staphylococcus auerus (JKB068	Data from publication for CAS no 7681-11-0
4	MIC	219.4 mg/l	growth inhibition	24 hrs	Escherichia coli (JKE029)	Data from publication for CAS no 7681-11-0
5	MIC	147.6 mg/l	growth inhibition	24 hrs	Bacillus subitilis (JKS007)	Data from publication for CAS no 7681-11-0
6	MIC	231.5 mg/l	growth inhibition	24 hrs	Clostridium sp. 1	Data from publication for CAS no 7681-11-0
7	MIC	200.9 mg/l	growth inhibition	24 hrs	Clostridium sp. 2	Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that MIC (Minimum Inhibitory Concentration) value is expected to be in range of147.6 to 518.4457 mg/l.