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EC number: 232-191-3 | CAS number: 7789-80-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish
Based on the various studies available with Klimish rating 2and 4 for the target substance Calcium iodate and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
LC0 |
100 mg/l |
mortality |
96 hrs |
Danio rerio |
Study Report for target chemical |
2 |
NOEC |
100 mg/l |
mortality |
7 days |
Danio rerio |
Study Report for target chemical |
3 |
LC50 |
558.5557 mg/l |
mortality |
96 hrs |
Oncorhynchus mykiss |
Predicted data for target chemical |
4 |
LC50 |
350 mg/l |
mortality |
96 hrs |
Oncorhynchus mykiss |
Data from publication for CAS no 7681-55-2 |
5 |
LC50 |
896 mg/l |
mortality |
96 hrs |
Oncorhynchus mykiss |
Data from publication for CAS no 7681-11-0 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC0 value was found to be 100 mg/l in 96 hrs study and the LC50 values was found to be in range of 350 to 896 mg/l in 96 hrs on the basis of mortality effect . Thus according to CLP criteria of aquatic classification it is concluded that the substance Calcium iodate is not toxic to Fish (Danio rerio, Oncorhynchus mykiss)
Long-term toxicity to fish
According to annex IX of column I ; Long-term toxicity testing on fish need not to be conducted as it is already provided as a part of Annex VII requirements.Therefore this study was considered to be waived.
Short-term toxicity to aquatic invertebrates
Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
LC50 |
236.1352 mg/l |
mortality |
48 hrs |
Daphnia magna |
Predicted data for target chemical |
2 |
LC50 |
226 mg/L.
|
mortality |
24 hrs |
Dreissena polymorpha |
Data from publication for CAS no 7681-11-0 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 226 to 236.1352 mg/l in a 24 to 48 hrs study on the basis of mortality effect . Thus according to CLP criteria of aquatic classification it is concluded that the substance calcium iodate is not toxic to aquatic invertebrate (Daphnia magna and Dreissena polymorpha)
Long-term toxicity to aquatic invertebrates
According to annex IX of column I; Long-term toxicity testing on invertebrate (species: Daphnia) need not to be conducted as it is already provided as a part of Annex VII requirements.Therefore this study was considered waived.
Toxicity to aquatic algae and cyanobacteria
Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
MIC |
843.1238 mg/l |
growth rate |
10 days |
Dunaliella salina |
Predicted data for target chemical |
2 |
MIC |
1124.559 mg/l |
growth rate |
10 days |
Cryptomonas sp. |
Predicted data for target chemical |
3 |
MIC |
2600.4mg/l |
growth rate |
10 days |
N. closterium |
Data from publication for CAS no 7681-11-0 |
4 |
MIC |
2590.7mg/l |
growth rate |
10 days |
Phaedactylum tricornutum |
Data from publication for CAS no 7681-11-0 |
5 |
MIC |
696.2mg/l |
growth rate |
10 days |
Chlorella sp. |
Data from publication for CAS no 7681-11-0 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that MIC (Minimum Inhibitory Concentration) value is expected to be in range of696.2 to2600.4 mg/l. Thus considering CLP Criteria for aquatic classification of the substance, it is concluded that Calcium iodate does not exhibit toxicity to green algae (Dunaliella salina, Cryptomonas sp, N. closterium, Phaedactylum tricornutum, Chlorella sp.)
Toxicity to microorganisms
Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
MIC |
509.603 mg/l |
growth inhibition |
24 hrs |
Clostridium sp. |
Predicted data for target chemical |
2 |
MIC |
518.4457 mg/l |
growth inhibition |
24 hrs |
Escherichia coli (JKE029) |
Predicted data for target chemical |
3 |
MIC |
358.3 mg/l |
growth inhibition |
24 hrs |
Staphylococcus auerus (JKB068 |
Data from publication for CAS no 7681-11-0 |
4 |
MIC |
219.4 mg/l |
growth inhibition |
24 hrs |
Escherichia coli (JKE029) |
Data from publication for CAS no 7681-11-0 |
5 |
MIC |
147.6 mg/l |
growth inhibition |
24 hrs |
Bacillus subitilis (JKS007) |
Data from publication for CAS no 7681-11-0 |
6 |
MIC |
231.5 mg/l |
growth inhibition |
24 hrs |
Clostridium sp. 1 |
Data from publication for CAS no 7681-11-0 |
7 |
MIC |
200.9 mg/l |
growth inhibition |
24 hrs |
Clostridium sp. 2 |
Data from publication for CAS no 7681-11-0 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that MIC (Minimum Inhibitory Concentration) value is expected to be in range of147.6 to 518.4457 mg/l.
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