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EC number: 939-607-9
CAS number: 1474044-65-9
for dose range finding study:
reactions were scored after 24 h. Results:
20%: severe erythema 2/2;
10%: severe erythema 2/2;
severe- moderate 2/2;
severe- moderate 4/4;
0.5%: moderate-slight 2/2;
0.2%: slight erythema 1/2;
0.1%: No erythema 2/2.
Results for main study:
grading: 0/20 (3/20 showed a grade of 0.5; in control 2/10 showed a
grade 0.5). Second grading: 0/20 (no erythema was observed in any of the
test substance tested has a narrower chain length distribution compared
to full coco. The results from this substance however are fully valid
for evaluation of TMAC as:
tested substance constitutes already for 70% TMAC, without some
additional shorter and longer chain lengths present..
study equivalent to the Buehler test protocol (OECD Guideline 406) was
conducted to determine the sensitising potential of the read-across
substance C12-18 TMAC (test conducted on C12-14 alkyl trimethyl ammonium
chloride). The chain length distribution of the test substance is
narrower than C12-18 TMAC, however, the study is considered valid to
assess this endpoint, because the tested substance is a constitute of
C12-18 TMAC (at 70%), without some additional shorter and longer chain
lengths present, and principally, aspects of sensitisation are related
to possible reactivity and protein binding, which are independent of
chain length. A pre-test was conducted to determine non-irritating
concentrations to use in the main study. For the main study the
induction was carried out at: topical 0.1% w/v in aqueous ethanol for 6
hours, repeated after 7 and 14 days. Challenge was done two weeks after
the last induction treatment (Day 28): control and test animals received
0.1% w/v in acetone for 6 hours on previously untreated site under
closed patches. After 18 hours the sites were treated with depilatory
cream, rinsed and dried. After 3 hours, challenge sites were evaluated
for erythema on a scale of 0-3. Evaluation was repeated 24 hours later.
Results of the first grading were: 0/20 (3/20 showed a grade of 0.5; in
control 2/10 showed a grade 0.5). Second grading: 0/20 (no erythema was
observed in any of the animals). Under the conditions of the Buehler
test, the test substance was not sensitizing.
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