Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked

Endpoint summary

Description of key information

The acute oral LD50 of Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked after single oral administration to female rats is > 2000 mg/kg bw.
The acute dermal LD50 of Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked after single dermal application in male and female rats is > 2000 mg/kg bw. 

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Additional information

Acute oral toxicity

In a GLP compliant study, according to OECD guideline 423, the acute oral toxicity of Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked following a single oral administration in female Wistar rats was investigated (Bioassay, 2012). Two groups of fasted animals (3/group) were treated by gavage with Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked in 1,2-propanediol at a dose level of 2000 mg/kg bw and observed for 14 days. All animals survived until the end of the study period. No clinical signs were observed during the course of the study. The mean body weight increased within the normal range throughout the study period. No macroscopic findings were observed at necropsy. The acute oral LD₅₀of Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked after single oral administration to female rats is > 2000 mg/kg bw.

Acute dermal toxicity

In a GLP compliant study, according to OECD guideline 402, the acute dermal toxicity of Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked following a single dermal application in male and female Wistar rats was investigated (Bioassay, 2012). A group animals (5/sex) was dermally exposed to Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked in 1,2-propanediol at a dose level of 2000 mg/kg bw for 24 hours under semi-occlusive dressing and observed for 14 days. All animals survived until the end of the study period. There were no signs of systemic toxicity and no signs of skin effects. The mean body weight of the male animals increased within the normal range throughout the study period. The mean body weight of the female animals decreased slightly during the first post-exposure observation week, probably due to the bandage procedure, and increased only marginal during the second post-exposure observation week. This effect is observed at times in the rat strain used, because in the required age range the female animals have already reached the phase of slow growth. No macroscopic pathologic abnormalities were noted in the animals examined at the end of the study. The acute dermal LD₅₀of Hexane, 1,6-diisocyanato, homopolymer, N-butyl-1-butanamine-blocked after single dermal application in male and female rats is > 2000 mg/kg bw.

Justification for classification or non-classification

Based on the available data, the test substance is not classified with regard to toxicity to acute toxicity according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP), respectively.