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EC number: 230-638-7
CAS number: 7237-83-4
order to assess the cutaneous allergenic potential of the substance, the
Maximization-Test was performed in 30 (20 test and 10 control) males and
females albino guinea pigs, in accordance with OECD Guideline No. 406
and the Directive 84/449/EEC,
intradermal induction of sensitization in the test group was performed
in the nuchal region with a 1% dilution of the test item in Oleum
arachidis and in mixture of Freund's Complete Adjuvant (FCA) /
physiological saline. The epidermal induction of sensitization was
conducted for 48 hours under occlusion with the test item at 100 % one
week after the intradermal induction. The animals of the control group
were induced with the vehicle and Freund's Complete Adjuvant.
weeks after epidermal induction the control and test animals were
challenged by epidermal application of the test item at 50 % in vaseline
and vaseline alone under occlusive dressing.
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