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EC number: 230-638-7 | CAS number: 7237-83-4
- Life Cycle description
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Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
The Magnusson & Kligman test performed with tris(oxiranylmethyl)benzen-1,2,4-tricarboxylate showed a significant potential to cause skin sensitisation.
Migrated from Short description of key information:
One skin sensitisation study (Maximization test) was performed with Guinea Pigs according to OECD 406. The intradermal induction was performed with tris(oxiranylmethyl)benzen-1,2,4-tricarboxylate at 1% in Oleum arachidis and the epidermal induction was performed with the undiluted test item.
The challenge was perfomed with tris(oxiranylmethyl)benzen-1,2,4-tricarboxylate at 50% in vaseline. After 24 hours 14 out of 20 animals were sensitised and after 48 hours all animals showed a skin sensitising effect.
Justification for classification or non-classification
- skin sensitisation:
Based on the above stated assessment of the skin sensitisation potential of tris(oxyranylmethyl)benzene-1,2,4 -tricarboxylate (100% of the animals sensitized in Magnuson & Kligman test) the substance needs to be classified as R43 (May cause sensitisation by skin contact) according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and Skin Sens. 1 (H317: may cause an allergic skin reaction) according CLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.
- respiratory sensitisation:
As no data on respiratory sensitization is available for tris(oxyranylmethyl)benzene-1,2,4 -tricarboxylate a classification is not possible according to Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC) and accordingCLP (Regulation (EC) No 1272/2008 Of The European Parliament And Of The Council) as implementation of UN-GHS in the EU.
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