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EC number: 230-638-7
CAS number: 7237-83-4
One in vivo skin irritation study was performed with tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate in New Zealand White rabbits. 0.5 mL of the undiluted test substance was applied to the shaved skin under semi-occlusive dressing during 4 hours. Slight erythema were observed in all three animals and full reversibility was noted within 10 days.One in vivo eye irritation study was performed with tris(oxiranylmethyl)benzen-1,2,4-tricarboxylate in New Zealand white rabbits. 0.1 mL of the test substance was placed into the conjunctival sac of the left eye of each animal. Moderate to severe irritation was observed in all animals. After 14 days all signs of irritation had disappeared.
One in vivo skin irritation study and one in vivo eye irritation study
were performed in New Zealand White rabbits. In both studies
tris(oxiranylmethyl)benzene-1,2,4-tricarboxylate showed irritating
potential. However, the effects were not sufficient for classification
as irritant to the skin. The effects were fully reversible within 10
days in the skin irritation study and within 14 days in the eye
Based on the above stated assessment of the
skin irritation potential of tris(oxyranylmethyl)benzene-1,2,4
-tricarboxylate the substance does not have to be classified according
to Council Directive 2001/59/EC and according to CLP (Regulation (EC) No
1272/2008 Of the European parliament and of the Council.
Base on the above assessment of the eye
irritation potential of tris(oxyranylmethyl)benzene-1,2,4
-tricarboxylate the substance does have to be classified as R36
Irritating to eyes according to Council Directive 2001/59/EC and
Category 2 (H319: Causes serious eye irritation) according to CLP
(Regulation (EC) No 1272/2008 Of the European parliament and of the
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