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EC number: 201-151-7 | CAS number: 78-86-4
For animals treated with a single dose of 2000 mg/kg bw a very slightly reduced activity (sedation) and piloerection was noted 1 to 3 hours following administration, but the animals were normal in appearance and behaviour afterwards. No animal died throughout the study.
The number of polychromatic erythrocytes with micronuclei was significantly incresed 24h post injection in the positive control animals. This confirms the sensitivity of the animal strain used. No significant differences between animals treated with 2 -chlorobutane and control animals were noted at 24, 48 and 72 hours following application. The number of polychromatic and normochromatic erythrocytes and the ratio polychromatic/normochromatiuc erythrocytes was not significantly different to the controls in animals treated with 2 -chlorobutane at any time. Thus, 2 -chlorobutane is considered negative for mutagenicity in this test.
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