Registration Dossier
Registration Dossier
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EC number: 227-575-2 | CAS number: 5894-60-0
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption, other
- Remarks:
- other: calculation
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The result was obtained by the valid application of an appropriate predictive method.
- Principles of method if other than guideline:
- Calculation according to USEPA Estimations Programs Interface (EPI) Suite®, version 4.0.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Type:
- log Koc
- Value:
- 5.6
- Remarks on result:
- other: Predicted using KOCWIN MCI method
- Type:
- log Koc
- Value:
- 2.4
- Remarks on result:
- other: Predicted using TGD non-hydrophobics Kow prediction method
- Conclusions:
- Log Koc values of 5.6 (KOCWIN MCI prediction method) and 2.4 (TGD Kow prediction method) were obtained using appropriate calculation methods. The results are considered to be reliable.
Reference
Description of key information
Log Kocof 5.6 (KOCWIN MCI prediction method) and 2.4 (TGD non-hydrophobics Kow prediction method).
Key value for chemical safety assessment
Additional information
Adsorption has been estimated for the hydrolysis product hexadecylsilanetriol using two separate estimation methodologies (USEPA SRC, 2009): (1) KOCWIN (version 2) estimation using first-order Molecular Connectivity Index (MCI) and (2) estimation based on log Kow using TGD (Technical Guidance Document) non-hydrophobics equation. Koc predictions based on log Kow and on MCI are both presented as neither method had been validated fully for this class of substance. The significance of the uncertainty in the Koc values predicted will be examined in the exposure assessment for this substance.
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