Registration Dossier
Registration Dossier
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EC number: 223-051-2 | CAS number: 3709-43-1
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative data base
- Title:
- No information
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource);Ciba-Geigy Limited (1986). Data extracted from the robust summary received by CBIC January 9, 2006 and posted to the HPV Challenge Program website February 8, 2006;Project Number 851037
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Data is from ACTOR and U.S. Environmental Protection Agency Hazard Characterization Document
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- EC Number:
- 223-051-2
- EC Name:
- Disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Cas Number:
- 3709-43-1
- Molecular formula:
- C14H10N2O10S2.2Na
- IUPAC Name:
- disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Details on test material:
- - Name of test material : disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Substance type: Organic
- Physical state: Solid
Purity : (60% test substance; 35% water)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Remarks:
- Distilled water
- Controls:
- not specified
- Amount / concentration applied:
- Dose : 0.5 g
- Duration of treatment / exposure:
- 4 hrs
- Observation period:
- 72 hrs
- Number of animals:
- three males
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Score:
- 0
- Remarks on result:
- other: No edema or erythema was observed. All scores were 0 (no edema or erythema). The animals gained weight over the course of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- disodium 4,4'-dinitrostilbene-2,2'-disulphonate was not irritating to rabbit skin in this assay
- Executive summary:
New Zealand White rabbits (three males) were exposed to disodium 4,4’-dinitrostilbene-2,2’-disulphonate (60% test substance; 35% water) at 500 mg under semi-occlusive conditions for 4 hours and observed for 72 hours following administration. No edema or erythema was observed. disodium 4,4’-dinitrostilbene-2,2’-disulphonate was not irritating to rabbit skin in this assay.
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