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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 to 27 Jun 2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Guideline study (solubility below limit of detection).
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Principles of method if other than guideline:
L142 A/57-66
GLP compliance:
no
Type of method:
column elution method
Water solubility:
< 0.05 mg/L
Temp.:
20 °C
pH:
>= 6.1 - <= 6.4

Quantitative determination of the analyte

 

Flow rate (mL/h)

Fraction No.

Water Solubility of test item)

mg/L

pH value

25.0

1 (1-2)

< 0.05

6.4

 

2 (3-4)

< 0.05

6.4

 

3 (5-6)

< 0.05

6.4

 

4 (7-8)

< 0.05

6.4

 

5 (9-10)

< 0.05

6.4

 

6 (11-12)

< 0.05

6.4

 

7 (13-14)

< 0.05

6.3

 

8 (15-16)

< 0.05

6.3

 

 

 

 

12.5

1 (1-2)

< 0.05

6.2

 

2 (3-4)

< 0.05

6.2

 

3 (5-6)

< 0.05

6.2

 

4 (7-8)

< 0.05

6.1

 

5 (9-10)

< 0.05

6.1

 

6 (11-12)

< 0.05

6.2

 

7 (13-14)

< 0.05

6.2

 

8 (15-16)

< 0.05

6.2

 

All analysed fractions (at 12.5 mL/h and 25 mL/h) contained below 0.05 mg/L (limit of detection) of the test item.

The calibration curve fits over the whole working range from 0.06 to 2.29 mg/L with r²=1. A quadratic fit was used.

In the course of recovery experiment, an average recovery rate of 85% was found.

Description of key information

< 0.05 mg/L (20 °C, pH 6.1 to 6.4)

Key value for chemical safety assessment

Additional information

The water solubility of the substance glycerol tri(2-ethylhexanoate) (CAS 7360-38-5) was determined using the column elution method according to EU A.6.