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EC number: 232-476-2
CAS number: 8050-15-5
In a human repeated insult patch test
(similar to Modified Draize Procedure), a group of two hundred nine
subjects (males and females) above the age of 16 were repeatedly exposed
to 0.2 gram of Resin acids and Rosin acids, hydrogenated, Me esters
using occluded patches applied to the skin. Induction applications were
made 3 times/week for 3 successive weeks. No skin responses were evident
during the induction phase of the study. A two-week rest period followed
the final induction application. Following the rest period, a challenge
application of the test substance (0.2 gram) was made to each subject.
During the challenge application, the test substance remained in contact
with the skin (at a naïve site) for a period of approximately 24 hours.
Observations of the challenge sites were conducted at 24 and 72 hours
post application. No dermal responses were noted at the challenge sites
during the two examinations. Under the conditions of this study, Resin
acids and Rosin acids, hydrogenated, Me esters did not cause a skin
sensitization reaction in humans.
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