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EC number: 239-556-6
CAS number: 15520-10-2
Acetylation phenotype and cumulated excretion of
1,6 -hexamethylene diamine and 6 -amino-hexanoic acid in urine following
oral intake of 1,6 -hexamethylene diamine
% of dose
1,6-hexamethylene diamine (HMD) was orally administered to six healthy
volunteers. After acid hydrolysis of the urine by hydrochloric acid, HMD
and the metabolite 6-aminohexanoic acid were quantified. In hydrolysed
urine, a mean of 0.28 mg (range 1 to 6%) of the administered dose (8,2
mg) was recovered as parent compound, and a mean of 0.8 mg (range <1 to
27%) as 6-aminohexanoic acid. The urinary excretion of both the
determined compounds was rapid, and the principal part (>90%) of the
elimination was completed within 10 h. The eliminary half life
determined was approx. 1.5 hours. There was a considerable
inter-individual variation in the excreted amounts, but the
intra-individual variation in the exaction of HMD was limited. The
subjects N-acetylator phenotype was determined by a dapsone test. Three
slow acetylators excreted lower amounts (mean 2% of given dose) of
1,6-hexamethylene diamine than three rapid ones (mean 5% of given dose).
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