2-methylpentane-1,5-diamine

Sensitisation data (human)

Administrative data

Endpoint:

sensitisation data (humans)

Type of information:

other: case report

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

Occupational contact allergy to the epoxy resin hardener 2-methylpentane-1,5-diamine

Author:

Susanne Darr-Foit, Johannes Geier, Peter Elsner, Sibylle Schliemann

Year:

2016

Bibliographic source:

Contact Dermatitis, 74, 115-116

Materials and methods

Type of sensitisation studied:

skin

Study type:

case report

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

other: Guideline of the German Contact Dermatitis Research Group (Schnuch et al., 2008)

Deviations:

not specified

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-methylpentane-1,5-diamine

EC Number:

239-556-6

EC Name:

2-methylpentane-1,5-diamine

Cas Number:

15520-10-2

Molecular formula:

C6H16N2

IUPAC Name:

2-methylpentane-1,5-diamine

Test material form:

liquid

Method

Type of population:

occupational

Ethical approval:

not specified

Subjects:

- Number of subjects exposed: 1
- Sex: male
- Age: 63 y
- Race: white
- Demographic information: none

Clinical history:

- History of allergy or casuistics for study subject or populations: not specified
- Symptoms, onset and progress of the disease: 4-years of work-related contact dermatitis comprising itching, burning, oozing of face, forearms, dorsal surfaces of hands when handling epoxy resin sytems
- Exposure history: work-related, no time span specified
- Aggravating factors both in home and workplace: not specified
- Family history: not specified
- Any other allergic or airway disorders: not specified
- Smoking history: not specified

Controls:

concurrent on exposed subject

Route of administration:

dermal

Details on study design:

TYPE OF TEST(S) USED: patch test (epicutaneous test)

ADMINISTRATION
- Type of application: occlusive
- Description of patch: small Finn Chambers on Scanpor tape (SmartPractice Europe, Reinbeck, Germany)
- Vehicle / solvent: petrolatum
- Concentrations: 0.25% MPMD
- Volume applied: not specified
- Testing/scoring schedule: not specified
- Removal of test substance: after 2 days


EXAMINATIONS
- Grading/Scoring system: not specified, (given as -,?,+,++,+++)
- Statistical analysis: no

Results and discussion

Results of examinations:

SYMPTOMS:
- Frequency, level, duration of symptoms observed: not specified

RESULT OF CASE REPORT:
see Table 1

DISCUSSION:
The authors state that it is probable that the patient was co-sensitized by co-exposure to MPMD and m-xylene diamine, as he handled an epoxy resin system containing both substances.

Any other information on results incl. tables

Table 1 (taken from Darr-Foit et al., 2016)

Substance and test concentration	reading on day 2 (D2)	D3	D6
2-Methylpentane-1,5-diamine 0.25%	?	++	+++

Applicant's summary and conclusion

Executive summary:

A positive patch test reaction to MPMD of a 63-year old male worker with a 4-year history of work-related contact dermatitis due to handling of epoxy resin systems  was observed. The authors state that it was probable that the patient was co-sensitized by co-exposure to MPMD and m-xylene diamine, as he handled an epoxy resin system containing both substances.