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EC number: 201-972-0 | CAS number: 90-17-5
The test compound did not elicit any microscopical changes at the different tested dose level 125, 500 & 1500 mg/kg b.wt (Table-11).
Group-I Vehicle Control
Group-II 125 mg/kg b.wt
Group-III 500 mg/kg b.wt
Group-IV 1500 mg/kg b.wt
Group-V Highest dose reversal group
Mild vascular congestion
Vascular congestion, infiltration of Neutrophils and necrotic changes in hepatocytes
Mild congestion and necrotic changes in tubular epithelium
Moderate to severe congestion glomerulus, vascular hemorrhage and necrotic changes in tubular epithelium
Spread of lymphoid tissue in red pulp
Infiltration of Neutrophils, increase white pulp
Infiltration of Neutrophils
Mild congestion and infiltration of Neutrophils in alveolar wall
Mild congestion in lung
TABLE- BODY WEIGHT OF RAT (gm)
TABLE: SUMMARY OF CLINICAL SIGNS
Group- I Vehicle control
Group- II 125 mg/kg b.wt
The Sub-acute Dermal toxicity study of the test chemical was conducted in wistar albino rats. Fifty healthy wistar albino rats were acclimatized for standard laboratory condition for period of one week. After acclimatization animal were divided into five groups (one control and four treated) each having five male and five female. All the animals were prepared 24 hrs prior to application of test compound. The test substance applied uniformly 125, 500 and 1500 mg/kg b.wt for at least 6 hours per day on a 7-day per week basis. A reversal group was also maintained in same manner at the highest test dose level 1500 mg/kg b.wt for period of 42 days.All the parameters were examined. No adverse effect on general health, growth, behavioural, neurological, haematological, clinical chemistry and urinalysis parameters, organ weights and gross and microscopic changes of the tissues/organs of the rats treated up to the dose level of 500 mg/kg body weight. Based on the findings of this study, the no observed adverse effect level (NOAEL) of the test chemical in rats was considered to be 500 mg/kg body weight and the No Observed Effect Level (NOEL) was considered to be 125 mg/kg b.wt.
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