Registration Dossier
Registration Dossier
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EC number: 207-975-3 | CAS number: 503-74-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: 3a: Significant methodological deficiences
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- grey literature
- Title:
- Safety Data Sheet, 31 Jan. 1972
- Author:
- Union Carbide
- Year:
- 1 972
- Bibliographic source:
- (cited from HSDB, 2003)
- Report date:
- 1972
- Title:
- Vol 2A - 2F, 4th ed., J. Wiley & Sons, N.Y., 1993-1994 (cited from HSDB 2003)
- Author:
- Clayton, G.D. and Clayton F.E. (eds.):
- Year:
- 2 003
- Report date:
- 2003
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
- Reference Type:
- review article or handbook
- Title:
- Aliphatic Carboxylic Acids, Saturated
- Author:
- Cragg ST
- Year:
- 2 001
- Bibliographic source:
- Bingham E, Cohrssen B, and Powell CH (eds.) Patty´s Industrial Hygiene and Toxicology (2005) John Wiley & Sons, N.Y., USA
- Report date:
- 2001
Materials and methods
Test material
- Reference substance name:
- Isovaleric acid
- EC Number:
- 207-975-3
- EC Name:
- Isovaleric acid
- Cas Number:
- 503-74-2
- Molecular formula:
- C5H10O2
- IUPAC Name:
- 3-methylbutanoic acid
- Details on test material:
- IUCLID4 Test substance: no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Amount / concentration applied:
- undiluted
Amount applied: 0.94 other: mg - Duration of treatment / exposure:
- unspecified
- Details on study design:
- Comment: no data
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information
- Executive summary:
According to HSDB (2003) 940 µg were applied; whereas this was 940 mg according to Cragg (2005; Patty's Toxicology, electronic version). Though there might have been typos, the method applied and the result obtained remain at present unclear.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
