Registration Dossier
Registration Dossier
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EC number: 207-975-3 | CAS number: 503-74-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to guideline study. Documentation scarce, but raw data are available upon request
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Inhalation risk test
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Isovaleric acid
- EC Number:
- 207-975-3
- EC Name:
- Isovaleric acid
- Cas Number:
- 503-74-2
- Molecular formula:
- C5H10O2
- IUPAC Name:
- 3-methylbutanoic acid
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- air
- Details on inhalation exposure:
- Air was guided through a 5-cm layer of test material contained in a wash bottle to generate a saturated vapour atmosphere
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 7 h
- Concentrations:
- saturated atmosphere
- No. of animals per sex per dose:
- 12 animals
Results and discussion
Effect levels
- Dose descriptor:
- LC0
- Effect level:
- 2 060 mg/m³ air
- Exp. duration:
- 7 h
- Remarks on result:
- other: Exposure to saturated atmosphere in Inhalation Risk Test. Effect level (2060 mg/m³) calculated.
- Mortality:
- rats survived inhalation exposure at saturation, exposure period 7 hours
Applicant's summary and conclusion
- Conclusions:
- The LC0 was 2060 mg/m³ in this study. All rats (n=12) survived inhalation exposure at saturation, exposure period 7 hours. Slight respiratory tract irritation was noted.
- Executive summary:
Inhalation risk test; similar to guideline (saturation exposure without analytical measurement). The saturation concentration can be calculated (using data from GESTIS: molecular weight 102.13; vapour pressure 0.5 mbar at 20°C; 1 ppm = 3.53 mg/m³). Result: the saturation concentration is 2060 mg/m³, i.e. 584 ppm. All rats (n=12) survived a 7-hr exposure period at the maximum attainable concentration, i.e. the LC0 -value was 2060 mg/m³.
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