Registration Dossier
Registration Dossier
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EC number: 207-975-3 | CAS number: 503-74-2
Endpoint summary
Administrative data
Description of key information
Additional information
Stability
Phototransformation in air
For the indirect photodegradation of isovaleric acid in air by the reaction with OH-radicals, a half-life of approx. 31.3 hours (2.6 days) was calculated (GUBDH, 2012, US EPA EPI Suite v4.10).
Hydrolysis
Due to its chemical structure and reactivity, isovaleric acid will not hydrolyse under environmental conditions. The structure of the molecule does not contain hydrolysable constituents (GUBDH, 2008).
Biodegradation
Biodegradation in water: screening test
Isovaleric acid has been shown to be readily biodegradable in two tests for ready biodegradability.
1. - test similar to OECD TG 301 C (Urano, 1986; RL2; KS)
2. - test similar to OECD TG 301 D (Dias, 1971; RL2; SS)
Biodegradation in water and sediment: simulation test
Tests need not be conducted, as isovaleric acid is readily biodegradable.
In addition, data are not required as only Annex VII data requirements have to be fulfilled.
Biodegradation in soil
Tests need not be conducted, as isovaleric acid is readily biodegradable. In addition, data are not required as only Annex VII data requirements have to be fulfilled.
Bioaccumulation
Bioaccumulation: aquatic/sediment
Not required as the substance is registered under provisions of Article 12(1)(c) of REACH.
As the log Kow of isovaleric acid is low (log Kow = 1.7, Sect. 4.7, OXEA, 2010) and the substance is readily biodegradable (Urano, 1986 and Dias 1971), the potential for bioaccumulation of isovaleric acid is low.
In addition, calculated Log BCF and log BAF (upper trophic) values of 0.5 and 0.748 respectively (US EPA EPI Suite v4.10, program component BCFBAF v3.01) indicate a low potential of isovaleric acid for bioaccumulation in aquatic organisms (GUBDH, 2012).
Terrestrial
No data available (data are not required as only Annex VII data requirements have to be fulfilled).
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Transport and Distribution
Adsorption/Desorption
In accordance with column 2 of REACH Annex VIII Nr 9.3.1, the study does not need to be conducted as the substance has a low potential for adsorption (log Kow < 3, see Sect. 4.7) and is readily biodegradable (see Sect. 5.2.1).
Based on a calculated Koc of 4.022 (log Koc = 0.6045), isovaleric acid is expected to have a high mobility in soil (GUBDH, 2012).
Henry’s Law constant
For isovaleric acid, a Henry's law constant of 8.333E-7 atm m³/mol was determined in an experimental study using equilibrium partial pressure measurements over aqueous solutions at 298.15 K (25°C) (Khan, 1992).
Calculations (GUBDH, 2012; US EPA EPI Suite v4.10) resulted in
Bond contribution method: HLC (25°C) = 1.28E-006 atm m³/mole
Group contribution method: HLC (25°C) = 9.96E-007 atm m³/mole
Isovaleric acid will volatilize from water only to a low degree.
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