Registration Dossier

Administrative data

Description of key information

28-day study: OECD guideline 407. GLP. 

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Study duration:
subacute
Species:
rat

Additional information

A daily oral administration of the test item to Wistar rats at a dose level of 200, 500 and 1000 mg/kg body mass over a time period of 28 days resulted in only mild systemic and local effects in test animals treated with the high dose (1000 mg /kg).

Justification for classification or non-classification

Based on the available data, the substance is not classified.