Registration Dossier
Registration Dossier
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EC number: 223-795-8 | CAS number: 4075-81-4
Endpoint summary
Administrative data
Description of key information
Additional information
Read-across approach
In the assessment of the environmental fate, ecotoxicity and toxicity of calcium dipropionate (CAS: 4075-81-4), a read-across approach from data for the metal (calcium) and the organic anion (propionate) is followed. This read-across strategy is based upon the observation that upon dissolution in aqueous media, calcium dipropionate completely dissociates and only is present in its dissociated form, i.e., as calcium and propionate ions. Data on the environmental fate, ecotoxicity and toxicity for both transformation products (calcium and propionate) together can therefore be combined in an additive approach to predict the corresponding properties of calcium dipropionate.
A detailed justification for the read-across approach is added as a separate document in section 13 of IUCLID.
Upon dissolution and dissociation of calcium dipropionate into calcium and propionate, both ions will each show the proper (bio)degradation, bioaccumulation and partitioning behaviour in the environment, as reported for the corresponding ion. The environmental fate and behaviour for calcium and propionate is predicted to be clearly different from each other, resulting in a different relative distribution over the environmental compartments (water, air, sediment and soil). Because the relative exposure to both constituent ions is hence predicted to be different from the original composition of calcium dipropionate, data for the ecotoxicological properties of this substance tested as such are considered less relevant for its effects and risk assessment and a read-across approach from data for both the calcium and propionate ions is preferred. The dose additivity approach is used to explain the ecotoxicological effects of calcium dipropionate based on the data for the individual transformation products (calcium and propionate ions).
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