Registration Dossier

Ecotoxicological information

Short-term toxicity to fish

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The acute toxicity of Cyclamen Aldehyde to freshwater fish has been estimated using ECOSAR v1.11. The fish 96-hr LC50 was predicted to be 1.092 mg/L (mono aldehyde SAR) and 3.032 mg/L (neutral organic SAR). The predicted values can be considered valid and reliable taking into consideration information on two close structural analogues.  Moreover, the experimental values for the analogues and predicted values for all 3 substances fall within the same acute aquatic hazard classification criterion range: E(L)C50 > 1mg/L and <= 10mg/L. For the purposes of the CSA,  the lowest predicted value was chosen.  

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1.092 mg/L

Additional information

The acute toxicity to fish of Cyclamen Aldehyde has been assessed using a QSAR approach. The QSAR approach works within the spirit of REACH and the stated aim of the legislation to reduce animal testing where possible. Cyclamen aldehyde was predicted to have a fish 96-hr LC50 of 1.092 mg/L and 3.032mg/L using respectively the ECOSAR v1.11 Mono Aldehyde and Neutral Organic SARs.

Both QSAR models are scientifically valid and both predictions are considered reliable taking into account measured and predicted values for two close structural analogues: 3-(3-isopropylphenyl)butanal; measured LC50 = 1.08 mg/l; predicted LC50 = 1.092 mg/L (Mono Aldehydes SAR), 3.032 (Neutral Organics SAR) and 3-4-(tert-butyl)phenyl-2 -methylpropanal; measured LC50 = 2.04 mg/L; predicted LC50 = 0.679mg/L (Mono Aldehydes SAR), 2.04 mg/l (Neutral Organics SAR).

For the purposes of the chemical safety assessment, the lowest predicted value of 1.092mg/L has been chosen.