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EC number: 257-036-7 | CAS number: 51181-50-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
48h EC50 100.9 mg/l EDTA-FeNa for Daphnia magna, corresponding to 97 mg/L HEDTA-FeNa
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 97 mg/L
Additional information
Four studies report on the toxicity of the test substance to Daphnia magna.
1. The toxicity of FeNaEDTA on Daphnia magna was tested in a 48 h static immobilisation test (Borrmann 2007). Test concentrations were measured and were within the range of 80% of the nominal concentration. The EC50 (mobility) was 100.9 mg/L (nominal) and the NOEC was 30 mg/L (reliability 1, Key study).
2. The acute toxicity (96h-LC50) of sodium ferric EDTA towards Daphnia magna was investigated in a multispecies test system (published by Ewell et al., 1986). The 96h-LC50 was 32 mg/l (nominal; published, reliability 2).
3. The acute toxicity of EDTA, Mn(II)+EDTA and Fe(III)+EDTA towards Daphnia magna was investigated (published by Sorvari and Sillanpaa 1996, Reliability 2). The 24h-EC50 for Fe(III)+EDTA expressed as Fe(III) (= 17 mg/l) equals the value for Fe(III) when tested without EDTA (16 mg/l).
The 24h-EC50 for Fe(III)+EDTA expressed as EDTA is 89.3 mg/l. This is a lower value then the 610 mg/l for EDTA on its own. This may be due to the presence of free Fe present in the EDTA-Fe mixture that is absent in the test with EDTA on its own. The 24h-EC50 expressed as the test substance is 128.3 mg/l.
4. In addition, an acute study with DTPA-FeNaH was performed in which low toxicity to daphnids was confirmed (Kean, 2013). The 48 h EC50 value was > 82.1 mg/L (measured conc).
The key study with 48h-EC50 = 100.9 mg/l was selected because this was the most relevant study providing a concrete EC50 and was carried out according to the guidelines and under GLP. The study by Kean gave a > value only. The other two studies were either longer (96h) or shorter and had other shortcomings and gaps of information.
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