Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From November 05, 2010 to November 16, 2010
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study conducted in compliance with international guidelines.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2011
Report date:
2011

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: Council Regulation (EC) No. 761/2009, 23 July 2009, Part A, amending Regulation (EC) No. 440/2008: Methods for the determination of physico-chemical properties, A.4 “Vapour pressure”
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
gas saturation method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride
EC Number:
695-745-7
Cas Number:
1079221-49-0
Molecular formula:
C9 H11 N3 O2, ClH
IUPAC Name:
2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Results and discussion

Vapour pressureopen allclose all
Temp.:
70.5 °C
Vapour pressure:
0.003 Pa
Temp.:
80.2 °C
Vapour pressure:
0.009 Pa
Temp.:
90 °C
Vapour pressure:
0.031 Pa
Temp.:
25 °C
Vapour pressure:
0 Pa
Remarks on result:
other: extrapolated from the vapor pressure curve

Applicant's summary and conclusion

Executive summary:

The purpose of this study was to determine the vapor pressure of the test item. Several techniques are available to determine the vapor pressure of a test item experimentally. These techniques are described in 92/69/EEC guideline A.4, in the OECD guideline 104 and in the Council Regulation (EC) No. 761/2009, A.4. Based on a model calculation (QSAR) the gas saturation method was applied in this main study. The vapor pressure of the test item was measured at test temperatures of 70 °C, 80 °C and 90 °C and was determined to be 2.6 x 10-3 Pa at 70 °C, 8.7 x 10-3 Pa at 80 °C and 3.1 x 10-2 Pa at 90 °C. The vapor pressure of the test item at 25 °C was extrapolated from the vapor pressure curve and was calculated to be 2.2 x 10-6 Pa at 25 °C.