Ethanol, 2-[(3-aminopyrazolo[1,5-a]pyridin-2-yl)oxy]-, hydrochloride (1:1)

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

July 30, 2010 - February 24, 2011

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP study conducted in compliance with international guidelines.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Report date:

2011

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: Themal analysis and capillary test

Test material

Test material information

Constituent 1

Reference substance name:

2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride

EC Number:

695-745-7

Cas Number:

1079221-49-0

Molecular formula:

C9 H11 N3 O2, ClH

IUPAC Name:

2-({3-aminopyrazolo[1,5-a]pyridin-2-yl}oxy)ethan-1-ol hydrochloride

Test material form:

solid: particulate/powder

Remarks:

migrated information: powder

Results and discussion

Melting / freezing point

Melting / freezing pt.:

>= 220 °C

Decomposition:

yes

Remarks on result:

other: The test item started melting under decomposition at about 220 C

Any other information on results incl. tables

The DSC-curve of the preliminary test (heating rate of 20 °C/min from 25 °C to 400 °C) showed a first endothermic heat effect at 166.1 °C. A second endothermic heat effect was observed at 218.2 °C, followed by a third endothermic heat effect starting at 231.0 °C. After the experiment, the sample had lost 47.2% of its mass and a black, foamed and carbonized residue remained in the sample cup. In order to determine the first endothermic heat effect more precisely, a DSC-run was recorded between 140 °C and 200 °C with a heating rate of 10 °C/min. An endothermic heat effect was observed starting at 160.3 °C. After the experiment, the test item was still a powder. Thus, this endothermic heat effect is not due to melting of the test item. A further DSC-run was recorded between 140 °C and 240 °C with a heating rate of 10 °C/min. During this run, the first endothermic heat effect was observed at 159.6 °C and a second endothermic heat effect was observed at 210.7 °C. After the experiment, the sample lost 13.0% of its mass and a black melt remained in the sample cup. To clarify the results of the DSC runs more precisely, further tests were performed using the capillary tester and visual detection. In a first test a total of three samples were heated up from 25 °C to 400 °C with a heating rate of 20 °C/min. At 175 °C the samples became darker. At 200 °C some black spots were detected. At 220 °C the color of the test item was changed completely to black. At 226 °C the samples started melting while expanding. In a second test two samples were heated up from 140 °C to 300 °C with a heating rate of 10°C/min. From 170 °C to 217 °C the color of the samples became darker. At 220 °C the color of the samples was changed completely to black and the test item started melting.

Applicant's summary and conclusion

Conclusions:

With regard to the DSC-runs and the capillary tests, it can be concluded that the test item started melting under decomposition at about 220 C.

Executive summary:

The melting temperature of the test item has been determined according to OECD 102 and Council Regulation (EC) No. 440/2008, 30 May 2008, Part A, Methods for the determination of physico-chemical properties, A.1 in GLP. With regard to the DSC-runs and the capillary tests, it can be concluded that the test item started melting under decomposition at about 220 C.