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EC number: 700-570-7 | CAS number: 1217271-49-2
The eye irritation potential of Sika Hardener MH was evaluated in the BCOP Test following OECD Guideline 437 dated September 2009. One valid experiment was performed.
Bovine corneas were used. They were collected from slaughtered cattle which were between 12 and 60 months old. The test item Sika Hardener MH was brought onto the cornea of a bovine eye which had been incubated with cMEM without phenol red at 32±1°C for one hour and whose opacity had been measured.
The test item was incubated on the cornea for 10 minutes at 32±1°C. After removal of the test item and two hours post-incubation, opacity and permeability values were measured.
Physiological sodium chloride solution was used as negative control. The negative control showed no irritating effect on the cornea.
10% sodium hydroxide solution was used as positive control. The positive control induced a very severe irritation on the cornea.
The test item Sika Hardener MH showed mild effects (according to ICCVAM classification) on the cornea of the bovine eye. The calculated IVIS (in vitro irritancy score) is 19.7830.
In conclusion, it can be stated that in this study and under the experimental conditions reported, the test item Sika HardenerMH possesses a mild eye irritation potential.
According to OECD 437, Sika Härter MH is considered as “non corrosive / no severe irritant”.
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