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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
from 2015-02-24 to 2015-02-25
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Version / remarks:
adopted 23. Mar. 2006
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Version / remarks:
dated 24 August 2009
Deviations:
no
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
effusion method: by loss of weight or by trapping vaporisate
Specific details on test material used for the study:
- Analytical purity: 97.5 %
- Lot/batch No.10191-Akm - AK220715
- Expiration date of the lot/batch: 2016-12-31
Key result
Temp.:
20 °C
Vapour pressure:
0.005 Pa
Temp.:
25 °C
Vapour pressure:
0.006 Pa

The measured values for temperature and vapour pressure were evaluated as follows:

Evaluation of Calculated Values

Parameter

T

Mean P

1/T

log P

Unit

K

Pa

1/K

log Pa

Values

303.2

6.53E-03

3.2982E-03

-2.1852

318.2

9.88E-03

3.1427E-03

-2.0052

333.2

1.68E-02

3.0012E-03

-1.7734

348.2

2.17E-02

2.8719E-03

-1.6631

 

 A graph with log P vs. 1/T was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression.

 

Parameters of Linear Regression

Parameter

Value

Slope

-1268.4

Intercept

1.9980

Correlation Coefficient r

-0.9943

Coefficient of Determination r2

0.9886

 

The following vapour pressures were determined experimentally and considered as valid:

T

T

P

Stand. Dev. P

RSD P

°C

K

Pa

Pa

%

30.0

303.2

6.53E-03

1.73E-03

26.6%

45.0

318.2

9.88E-03

1.73E-03

17.5%

60.0

333.2

1.68E-02

1.07E-03

6.3%

75.0

348.2

2.17E-02

4.56E-03

21.0%

 

Conclusions:
The vapour pressure of the test item was determined to be 0.00469 Pa at 20 °C and 0.00554 Pa at 25 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at three different temperatures (30, 45, 60 and 75 °C) using the effusion method (weight loss). All measured values showed good reproducibility, giving relative standard deviations of less than 30 %, and perfect correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated to be 0.00469 Pa at 20 °C and 0.00554 Pa at 25 °C, respectively.

Description of key information

The vapour pressure of the test item was determined to be 0.00469 Pa at 20 °C and 0.00554  Pa at 25 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0.005 Pa
at the temperature of:
20 °C

Additional information

A study was conducted according to OECD TG 104, Regulation (EC) No 440/2008 method A.4 and OPPTS 830.7950 to determine the vapour pressure of the test item. The vapour pressure of the test item was determined at three different temperatures (30, 45, 60 and 75 °C) using the effusion method (weight loss). All measured values showed good to medium reproducibility, giving relative standard deviations of less than 30 %, and perfect correlation. Therefore, the result of the test according to the guideline criteria was considered to be valid. The vapour pressure was calculated using the linear regression equation of the Log P versus 1/T function. The vapour pressure was calculated to be 0.00469 Pa at 20 °C and 0.00554 Pa at 25 °C, respectively.